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The impact of the d...
The impact of the distribution of isoforms on CaMKII activation
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- Sandström, Malin (author)
- KTH,Beräkningsbiologi, CB
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- Hjorth, Johannes (author)
- KTH,Beräkningsbiologi, CB
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- Lansner, Anders (author)
- KTH,Beräkningsbiologi, CB
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- Hellgren Kotaleski, Jeanette (author)
- KTH,Beräkningsbiologi, CB
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Neurocomputing. - : Elsevier BV. - 0925-2312. ; 69:10-12, s. 1010-1013
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We have developed a computational model of the regulation of alpha- and beta-CaMKII activity, in order to examine (i) the importance of neighbour subunit interactions and (ii) the effect the higher CaMCa4 affinity of beta-CaMKII has on the holoenzyme activity in different configurations with the same alpha: beta ratio. The model consists of a deterministic biochemical network coupled to stochastic activation of CaMKII The results suggest that CaMKII holoenzyme activity is non-linear and dependent on the holoenzyme configuration of isoforms. This is especially pronounced in situations with a high-dephosphorylation rate of CaMKII.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Systemvetenskap, informationssystem och informatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Information Systems (hsv//eng)
Keyword
- CaMKII; Plasticity; Computer modelling; Stochastic model
- Computer and systems science
- Data- och systemvetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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