Surface Functionalization of Porous Resorbable Scaffolds by Covalent Grafting

• Resorbable porous scaffold discs and solid films were prepared from poly[(1,5-dioxepan-2one)-co-(L-lactide)] and poly [(epsilon-caprolactone)-co-(L-lactide)]. The surfaces of the scaffolds were functionalized to increase their hydrophilicity. A total of 90 samples were prepared to cover all important combinations of experimental and material factors, and all experimental data were fitted by a partial least square model. As a result of grafting, the porous discs and solid films exhibited a tremendous increase in wettability. The functionalized discs were hygroscopic so that water was instantly absorbed and thoroughly wet the substrates.

Subject headings

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)

Keyword

Biocompatibility; Functionalization of polymers; Grafting; Scaffolds; Surface modification; ABS resins; Biocompatibility; Curve fitting; Film preparation; Functional polymers; Grafting (chemical); Ketones; Surfaces; Caprolactone; Covalent grafting; Experimental datum; Functionalization of polymers; Functionalized; Grafting; Lactide; Material factors; Partial least square models; Porous scaffolds; Solid films; Surface functionalization; Surface modification; 1

5 benzodioxepane derivative; molecular scaffold; polycaprolactone; polylactide; lactide caprolactone copolymer; lactide-caprolactone copolymer; polyester; water; article; chemical binding; controlled study; covalent grafting; hydrophilicity; partial least squares regression; porosity; surface property; water absorption; wettability; absorption; chemistry; hydrophobicity; Absorption; Hydrophobicity; Polyesters; Porosity; Water; Wettability

Polymer chemistry

Polymerkemi

Publication and Content Type

ref (subject category)

art (subject category)