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Catalytic Self-Scre...
Catalytic Self-Screening of Cholinesterase Substrates from a Dynamic Combinatorial Thioester Library
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- Larsson, Rikard (author)
- KTH,Kemi
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- Pei, Zhichao (author)
- KTH,Kemi
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- Ramström, Olof (author)
- KTH,Kemi
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(creator_code:org_t)
- Wiley, 2004
- 2004
- English.
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In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 43:28, s. 3716-3718
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Simply the best: Dynamic combinatorial chemistry coupled to enzyme catalysis was used to identify enzyme substrates in a library constructed from a series of thioesters and thiols by transesterification. The library was directly coupled to the catalytic action of acetylcholinesterase, which selectively hydrolyzed the best substrate candidates (see schematic representation). The process allowed rapid identification of discrete substrates.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- combinatorial chemistry; enzyme catalysis hydrolysis; proteomics; transesterification
- Organic chemistry
- Organisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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