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Build-up of Collagen and Hyaluronic Acid Polyelectrolyte
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- Johansson, Jan-Å (author)
- Ångström Laboratory, Department of Materials Chemistry, Uppsala University
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- Halthur, Tobias (author)
- RISE,YKI – Ytkemiska institutet
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- Herranen, Merja (author)
- Uppsala universitet,Institutionen för materialkemi,Oorganisk kemi,Polymerkemi,oorganisk kemi,Ångström Laboratory, Department of Materials Chemistry, Uppsala University
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- (creator_code:org_t)
- 2005-03-03
- 2005
- English.
- In: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 6:3, s. 1353-1359
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We have used a novel polyelectrolyte multilayer (PEM) coating consisting of the polyelectrolytes collagen and hyaluronic acid. The build-up by the layer-by-layer deposition technique is outlined by ex situ and in situ ellipsometric measurements. When collagen was added, the thickness of the PEM was increased, and the refractive index was decreased. Corresponding but opposite effects were noted when hyaluronic acid was added. These changes are considered to be explained by a diffusion mechanism. It was also found that the PEM layers were unstable at physiological pH. However, by cross-linking using N-(3-di-methylaminopropyl)-N-ethylcarbodiimide together with N-hydroxysuccinimide, a stable PEM layer resulted. These tissue friendly PEM layers are expected to have a great impact in the design of artificial extracellular matrixes. Also, the insertion of fluorescence labels demonstrates the potential for incorporation of other functionalities.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Oorganisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Inorganic Chemistry (hsv//eng)
Keyword
- Carboxylic acids
- Collagen
- Coloring
- Crosslinking
- Deposition
- Diffusion
- Ellipsometry
- Fluorescence
- Multilayers
- pH effects
- Physiology
- Polyelectrolytes
- Refractive index
- Hyaluronic acid
- Layer-by-layer deposition mechanism
- Polyelectrolyte multilayers (PEM)
- Surface and colloid chemistry
- Yt- och kolloidkemi
- Inorganic chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Johansson, Jan-Å
- Halthur, Tobias
- Herranen, Merja
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- Elofsson, Ulla
- Hilborn, Jöns
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- Royal Institute of Technology
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