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Simulation of HyperSPECT : a high-resolution small-animal system with in-line x-ray optics

Tibbelin, Sandra, 1980- (author)
KTH,Medicinsk bildfysik
Nillius, Peter (author)
KTH,Medicinsk bildfysik
Danielsson, Mats (author)
KTH,Medicinsk bildfysik
 (creator_code:org_t)
2012-03-07
2012
English.
In: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 57:6, s. 1617-1629
  • Journal article (peer-reviewed)
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  • SPECT has become an important tool in pre-clinical applications. Small-animal imaging systems based on the use of one or more pinhole collimators now reach sub-half-mm resolution but unfortunately suffer from a compromise between sensitivity and resolution due to the pinhole collimators. We propose a small-animal SPECT system based not on pinholes but on in-line x-ray optics, which is rare in medical imaging systems for nuclear medicine. The x-ray lenses are optimized for 27 keV for low-energy imaging with iodine-125. We believe that this new system, HyperSPECT, can simultaneously improve on sensitivity and resolution compared to today's state-of-the-art systems. A full three-dimensional simulation of the system has been performed including the prism-array lenses, pre-and post-collimators and scintillator-based detector. Images of capillary phantoms have been reconstructed using an iterative image reconstruction method. Sensitivity was uniformly 0.37% throughout the 1 cm diameter spherical field of view and rod sizes of around 100 mu m diameter were distinguishable in the images of simulated capillary phantoms. These results indicate an increase in resolution by a factor of 5 during a simultaneous increase in sensitivity by a factor of 2 compared to the current state-of-the-art small-animal SPECT systems.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

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Nillius, Peter
Danielsson, Mats
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