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X-ray phase contras...
X-ray phase contrast for CO2 microangiography
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- Lundström, Ulf (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Larsson, Daniel H. (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Burvall, Anna (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Takman, Per A. C. (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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- Scott, L. (author)
- Karolinska Institutet
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- Brismar, H. (author)
- Karolinska Institutet
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- Hertz, Hans M. (author)
- KTH,Biomedicinsk fysik och röntgenfysik
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(creator_code:org_t)
- 2012-04-13
- 2012
- English.
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In: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 57:9, s. 2603-2617
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We demonstrate a laboratory method for imaging small blood vessels using x-ray propagation-based phase-contrast imaging and carbon dioxide (CO2) gas as a contrast agent. The limited radiation dose in combination with CO2 being clinically acceptable makes the method promising for small-diameter vascular visualization. We investigate the possibilities and limitations of the method for small-animal angiography and compare it with conventional absorption-based x-ray angiography. Photon noise in absorption-contrast imaging prevents visualization of blood vessels narrower than 50 mu m at the highest radiation doses compatible with living animals, whereas our simulations and experiments indicate the possibility of visualizing 20 mu m vessels at radiation doses as low as 100 mGy. Experimental computed tomography of excised rat kidney shows blood vessels of diameters down to 60 mu m with improved image quality compared to absorption-based methods. With our present prototype x-ray source, the acquisition time for a tomographic dataset is approximately 1 h, which is long compared to the 1-20 min common for absorption-contrast micro-CT systems. Further development of the liquid-metal-jet microfocus x-ray sources used here and high-resolution x-ray detectors shows promise to reduce exposure times and make this high-resolution method practical for imaging of living animals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Angiography
- Blood vessels
- Carbon dioxide
- Dosimetry
- Image quality
- Imaging techniques
- Visualization
- X ray apparatus
- X rays
Publication and Content Type
- ref (subject category)
- art (subject category)
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