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Degradable amorphou...
Degradable amorphous scaffolds with enhanced mechanical properties and homogeneous cell distribution produced by a three-dimensional fiber deposition method
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- Sun, Yang, 1983- (author)
- KTH,Polymerteknologi
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- Finne-Wistrand, Anna (author)
- KTH,Polymerteknologi
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- Albertsson, Ann-Christine (author)
- KTH,Polymerteknologi
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- Xing, Zhe (author)
- Dept. of Clinical Dentistry-Center for Clinical Dental Research, Faculty of Medicine and Dentistry, University of Bergen, Norway
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- Mustafa, Kamal (author)
- Dept. of Clinical Dentistry-Center for Clinical Dental Research, Faculty of Medicine and Dentistry, University of Bergen, Norway
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- Hendrikson, Wim J. (author)
- Department of Tissue Regeneration, University of Twente, The Netherlands
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- Grijpma, Dirk W. (author)
- Dept. of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, Enschede, The Netherlands
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- Moroni, Lorenzo (author)
- Department of Tissue Regeneration, University of Twente, The Netherlands
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(creator_code:org_t)
- 2012-05-24
- 2012
- English.
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In: Journal of Biomedical Materials Research. Part A. - : Wiley. - 1549-3296 .- 1552-4965. ; 100A:10, s. 2739-2749
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The mechanical properties of amorphous, degradable, and highly porous poly(lactide-co-caprolactone) structures have been improved by using a 3D fiber deposition (3DF) method. Two designs of 3DF scaffolds, with 45 degrees and 90 degrees layer rotation, were printed and compared with scaffolds produced by a salt-leaching method. The scaffolds had a porosity range from 64% to 82% and a high interconnectivity, measured by micro-computer tomography. The 3DF scaffolds had 89 times higher compressive stiffness and 35 times higher tensile stiffness than the salt-leached scaffolds. There was a distinct decrease in the molecular weight during printing as a consequence of the high temperature. The chain microstructure was, however, not affected; the glass transition temperature and the decomposition temperature were constant. Human OsteoBlast-like cells were cultured in vitro and the cell morphology and distribution were observed by scanning electron microscopy and fluorescence microscopy. The cell distribution on the 3DF scaffolds was more homogeneous than the salt-leached scaffolds, suggesting that 3DF scaffolds are more suitable as porous biomaterials for tissue engineering. These results show that it is possible to design and optimize the properties of amorphous polymer scaffolds. The 3DF method produce amorphous degradable poly(lactide-co-caprolactone) that are strong and particularly suitable for cell proliferation.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
Keyword
- 3D fiber deposition method
- amorphous degradable copolymer
- aliphatic polyester
- scaffold
- cell distribution
Publication and Content Type
- ref (subject category)
- art (subject category)
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