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Oxadiazole isomers :
Oxadiazole isomers : all bioisosteres are not created equal
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Goldberg, Kristin (author)
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Groombridge, Sam (author)
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Hudson, Julian (author)
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Leach, Andrew G. (author)
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MacFaul, Philip A. (author)
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Pickup, Adrian (author)
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Poultney, Ruth (author)
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Scott, James S. (author)
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- Svensson, Per H. (author)
- KTH,Kemi,Oorganisk Kemi/L Kloo
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Sweeney, Joseph (author)
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(creator_code:org_t)
- Royal Society of Chemistry (RSC), 2012
- 2012
- English.
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In: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 3:5, s. 600-604
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- article
- drug half life
- drug protein binding
- drug solubility
- drug stability
- drug structure
- drug synthesis
- human
- hydrogen bond
- isomer
- lipophilicity
- mouse
- nonhuman
- plasma protein binding
- priority journal
- rat
- structure analysis
- substitution reaction
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Goldberg, Kristi ...
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Groombridge, Sam
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Hudson, Julian
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Leach, Andrew G.
-
MacFaul, Philip ...
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Pickup, Adrian
-
show more...
-
Poultney, Ruth
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Scott, James S.
-
Svensson, Per H.
-
Sweeney, Joseph
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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MedChemComm
- By the university
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Royal Institute of Technology