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Association of Gene...
Association of Genes in the NF-κB Pathway with Antibody-Positive Primary Sjögren's Syndrome
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- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi,Uppsala University, Sweden
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- Wang, Chuan (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Vasaitis, Lilian (author)
- Uppsala universitet,Reumatologi,Uppsala University, Sweden
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- Eriksson, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Theander, Elke (author)
- Lund University, Sweden
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- Kvarnström, Marika (author)
- Karolinska Institutet
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- Forsblad-d'Elia, Helena (author)
- University of Gothenburg, Sweden,Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg
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- Jazebi, Helmi (author)
- Karolinska Institutet, Stockholm, Sweden
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- Sjöwall, Christoffer (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Reksten, Tove Ragna (author)
- University of Bergen, Norway
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- Brun, Johan G. (author)
- Haukeland University Hospital, Bergen, Norway
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- Jonsson, Malin V. (author)
- University of Bergen, Norway
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- Johnsen, Svein J. (author)
- Stavanger University Hospital, Norway
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- Wahren-Herlenius, Marie (author)
- Karolinska Institutet
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- Omdal, Roald (author)
- Stavanger University Hospital, Norway
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- Jonsson, Roland (author)
- University of Bergen, Norway
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- Bowman, Simon (author)
- University Hospital Birmingham, UK
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- Ng, Wan-Fai (author)
- Newcastle University, UK
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- Eloranta, Maija-Leena (author)
- Uppsala universitet,Reumatologi,Uppsala University, Sweden
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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(creator_code:org_t)
- 2013-10-27
- 2013
- English.
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In: Scandinavian Journal of Immunology. - : Wiley-Blackwell. - 0300-9475 .- 1365-3083. ; 78:5, s. 447-454
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Primary Sjogrens syndrome (SS) is a systemic autoimmune inflammatory disease characterized by focal lymphocytic infiltrates in the lachrymal and salivary glands and autoantibodies against the SSA/Ro and SSB/La antigens. Experimental studies have shown an activation of NF-B in primary SS. NF-B activation results in inflammation and autoimmunity and is regulated by inhibitory and activating proteins. Genetic studies have shown an association between multiple autoimmune diseases and TNFAIP3 (A20) and TNIP1 (ABIN1), both repressors of NF-B and of IKBKE (IKK epsilon), which is an NF-B activator. The aim of this study was to analyse single nucleotide polymorphisms (SNPs) in the IKBKE, NFKB1, TNIP1 and TNFAIP3 genes for association with primary SS. A total of 12 SNPs were genotyped in 1105 patients from Scandinavia (Sweden and Norway, n=684) and the UK (n=421) and 4460 controls (Scandinavia, n=1662, UK, n=2798). When patients were stratified for the presence of anti-SSA and/or anti-SSB antibodies (n=868), case-control meta-analysis found an association between antibody-positive primary SS and two SNPs in TNIP1 (P=3.4x10(-5), OR=1.33, 95%CI: 1.16-1.52 for rs3792783 and P=1.3x10(-3), OR=1.21, 95%CI: 1.08-1.36 for rs7708392). A TNIP1 risk haplotype was associated with antibody-positive primary SS (P=5.7x10(-3), OR=1.47, 95%CI: 1.12-1.92). There were no significant associations with IKBKE, NFKB1 or TNFAIP3 in the meta-analysis of the Scandinavian and UK cohorts. We conclude that polymorphisms in TNIP1 are associated with antibody-positive primary SS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Nordmark, Gunnel
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Wang, Chuan
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Vasaitis, Lilian
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Eriksson, Per
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Theander, Elke
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Kvarnström, Mari ...
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show more...
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Forsblad-d'Elia, ...
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Jazebi, Helmi
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Sjöwall, Christo ...
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Reksten, Tove Ra ...
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Brun, Johan G.
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Jonsson, Malin V ...
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Johnsen, Svein J ...
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Wahren-Herlenius ...
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Omdal, Roald
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Jonsson, Roland
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Bowman, Simon
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Ng, Wan-Fai
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Eloranta, Maija- ...
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Syvänen, Ann-Chr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Linköping University
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Umeå University
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Uppsala University
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Karolinska Institutet