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Cold Exposure Promo...
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
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- Dong, Mei (author)
- Shandong University, Peoples R China
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- Yang, Xiaoyan (author)
- Shandong University, Peoples R China
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- Lim, Sharon (author)
- Karolinska Institutet
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- Cao, Ziquan (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet
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- Honek, Jennifer (author)
- Karolinska Institutet
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- Lu, Huixia (author)
- Shandong University, Peoples R China
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- Zhang, Cheng (author)
- Shandong University, Peoples R China
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- Seki, Takahiro (author)
- Karolinska Institutet
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- Hosaka, Kayoko (author)
- Karolinska Institutet
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- Wahlberg, Eric (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland
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- Yang, Jianmin (author)
- Shandong University, Peoples R China
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- Zhang, Lei (author)
- Shandong University, Peoples R China
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- Länne, Toste (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Thorax-kärlkliniken i Östergötland
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- Sun, Baocun (author)
- Tianjin Medical University, Peoples R China
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- Li, Xuri (author)
- Sun Yat Sen University, Peoples R China
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- Liu, Yizhi (author)
- Sun Yat Sen University, Peoples R China
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- Zhang, Yun (author)
- Shandong University, Peoples R China
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- Cao, Yihai (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier (Cell Press), 2013
- 2013
- English.
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In: Cell Metabolism. - : Elsevier (Cell Press). - 1550-4131 .- 1932-7420. ; 18:1, s. 118-129
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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http://www.cell.com/...
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https://doi.org/10.1...
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Abstract
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- Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development of atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E-/- [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition. Furthermore, marked increase of inflammatory cells and plaque-associated microvessels were detected in the cold-acclimated ApoE(-/-) and Ldlr(-/-) mice, leading to plaque instability. Deletion of uncoupling protein 1 (UCP1), a key mitochondrial protein involved in thermogenesis in brown adipose tissue (BAT), in the ApoE(-/-) strain completely protected mice from the cold-induced atherosclerotic lesions. Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE(-/-) mice from plaque development. These findings provide mechanistic insights on low-temperature-associated cardiovascular risks.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Dong, Mei
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Yang, Xiaoyan
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Lim, Sharon
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Cao, Ziquan
-
Honek, Jennifer
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Lu, Huixia
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show more...
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Zhang, Cheng
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Seki, Takahiro
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Hosaka, Kayoko
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Wahlberg, Eric
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Yang, Jianmin
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Zhang, Lei
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Länne, Toste
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Sun, Baocun
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Li, Xuri
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Liu, Yizhi
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Zhang, Yun
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Cao, Yihai
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show less...
- Articles in the publication
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Cell Metabolism
- By the university
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Linköping University
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Karolinska Institutet