Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma

Discussion page 993
BACKGROUND: Hepatic metastases from medullary thyroid carcinoma (MTC) may impair quality of life by hypercalcitonemia-associated diarrhea and pain. In this prospective study, the effect of selective arterial chemoembolization (SACE) was evaluated.METHODS: Eleven patients with hepatic metastases from MTC received 1 to 9 courses of SACE using epirubicine. Symptomatic, biochemical, and morphologic responses on SACE were recorded.RESULTS: Symptomatic response was observed in all symptomatic patients. However, biochemical and radiologic response occurred only in 6 patients. Liver function was not affected by SACE. One patient with unexpected concurrent pheochromocytoma metastases died after the first course. Development of side effects in the course was observed in 8 patients but were only World Health Organization grade 1. Patients' satisfaction with SACE was excellent. Long-term follow-up found 7 patients alive (1-72 months). Three patients died with tumor 6, 12, and 24 months after SACE, respectively.CONCLUSION: SACE provided good symptom palliation for the majority of patients with hepatic metastases from MTC. However, transient remission or stabilization of hepatic metastases resulted in only 60%. Further studies using a randomized protocol are required.

Brauckhoff, MichaelMartin-Luther University of Halle-Wittenberg, Germany (author)
Behrmann, CurdMartin-Luther University of Halle-Wittenberg, Germany (author)
Sekulla, CarstenMartin-Luther University of Halle-Wittenberg, Germany (author)
Ukkat, JörgMartin-Luther University of Halle-Wittenberg, Germany (author)
Brauckhoff, KatrinMartin-Luther University of Halle-Wittenberg, Germany (author)
Gimm, OliverMartin-Luther University of Halle-Wittenberg, Germany(Swepub:liu)oligi51 (author)
Dralle, HenningMartin-Luther University of Halle-Wittenberg, Germany (author)
Martin-Luther University of Halle-Wittenberg, Germany (creator_code:org_t)

By the author/editor: Lorenz, Kerstin; Brauckhoff, Mich ...; Behrmann, Curd; Sekulla, Carsten; Ukkat, Jörg; Brauckhoff, Katr ...; show more...; Gimm, Oliver; Dralle, Henning; show less...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.