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Persistent organic ...
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Sjöberg Lind, YlvaDepartment of Emergency Medicine, Linköping University Hospital,Dept Emergency Med, Linköping University Hospital, Linköping, Sweden
(author)
Persistent organic pollutants and abnormal geometry of the left ventricle in the elderly
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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Lippincott Williams & Wilkins,2013
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Numbers
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LIBRIS-ID:oai:DiVA.org:liu-102411
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-102411URI
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https://doi.org/10.1097/HJH.0b013e32836221b3DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-54794URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212428URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)||Swedish Research Council (VR)||
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Background:Established risk factors for left ventricular hypertrophy (LVH) are hypertension, diabetes, and obesity. However, as these risk factors explain only part of the variation in left ventricular mass, we investigated whether persistent organic pollutants (POPs) might also play a role in LVH, because exposure to polychlorinated biphenyl 126 induced cardiac growth in rats.Methods:In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS), left ventricular mass index (LVMI), relative wall thickness (RWT), and geometric groups of LVH, were determined by echocardiography and 21 POPs were measured by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/HRMS) in 1016 individuals aged 70 years. All individuals with a history of myocardial infarction were excluded from analysis (n=72).Results:Several of the POPs were related to abnormal left ventricular geometry before adjustment for established risk factors, but lost in significance following adjustment. However, the pesticide hexachlorobenzene (HCB) levels were significantly related to RWT, and concentric left ventricular remodeling, also following adjustment for sex, blood pressure, antihypertensive treatment, diabetes, and BMI (Pandlt;0.0001).Conclusion:In this cross-sectional study, circulating levels of HCB were related to increased wall thickness of the left ventricle and concentric left ventricular remodeling, independently of LVH risk factors, suggesting a role of this environmental contaminant in abnormal growth of the left ventricle.
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden(Swepub:uu)larslind
(author)
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Salihovic, Samira,1985-Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden(Swepub:oru)sasc
(author)
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van Bavel, Bert,1963-Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University, Sweden(Swepub:oru)bvl
(author)
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Lind, P. MonicaUppsala universitet,Arbets- och miljömedicin,Uppsala University, Sweden(Swepub:uu)monilind
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Department of Emergency Medicine, Linköping University HospitalDept Emergency Med, Linköping University Hospital, Linköping, Sweden
(creator_code:org_t)
Related titles
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In:Journal of Hypertension: Lippincott Williams & Wilkins31:8, s. 1547-15530263-63521473-5598
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