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Comparative metabol...
Comparative metabolomics of muscle interstitium fluid in human trapezius myalgia: an in vivo microdialysis study
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- Hadrévi, Jenny, 1977- (author)
- Högskolan i Gävle,Umeå universitet,Anatomi,Arbetshälsovetenskap,Centrum för belastningsskadeforskning,Umeå University, Sweden
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- Ghafouri, Bijar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Smärt och rehabiliteringscentrum,Arbets- och miljömedicin,Avdelningen för samhällsmedicin,Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University and Pain and Rehabilitation Centre, County Council of Östergötland, SE 581 85 Linköping, Sweden
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- Sjörs, Anna (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Hälsouniversitetet,Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University and Pain and Rehabilitation Centre, County Council of Östergötland, SE 581 85 Linköping, Sweden; Institute of Stress Medicine, Carl Skottsbergs gata 22B, SE 41319 Gothenburg, Sweden
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- Antti, Henrik (author)
- Umeå universitet,Kemiska institutionen,Department of Chemistry, Faculty of Science and Technology, Umeå University,Umeå University, Sweden
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- Larsson, Britt (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för samhällsmedicin,Hälsouniversitetet,Smärt och rehabiliteringscentrum,Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University and Pain and Rehabilitation Centre, County Council of Östergötland, SE 581 85 Linköping, Sweden
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- Crenshaw, Albert G. (author)
- Högskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning,University of Gavle, Sweden
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- Gerdle, Björn (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för samhällsmedicin,Hälsouniversitetet,Smärt och rehabiliteringscentrum,Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University and Pain and Rehabilitation Centre, County Council of Östergötland, SE 581 85 Linköping, Sweden
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- Hellström, Fredrik, 1973- (author)
- Högskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning,University of Gavle, Sweden
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(creator_code:org_t)
- 2013-09-28
- 2013
- English.
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In: European Journal of Applied Physiology. - : Springer Verlag (Germany). - 1439-6319 .- 1439-6327. ; 113:12, s. 2977-2989
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Abstract
Subject headings
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- The mechanisms behind trapezius myalgia are unclear. Many hypotheses have been presented suggesting an altered metabolism in the muscle. Here, muscle microdialysate from healthy and myalgic muscle is analysed using metabolomics. Metabolomics analyse a vast number of metabolites, enabling a comprehensive explorative screening of the cellular processes in the muscle. less thanbrgreater than less thanbrgreater thanMicrodialysate samples were obtained from the shoulder muscle of healthy and myalgic subjects that performed a work and stress test. Samples from the baseline period and from the recovery period were analysed using gas chromatography-mass spectrometry (GC-MS) together with multivariate analysis to detect differences in extracellular content of metabolites between groups. Systematic differences in metabolites between groups were identified using multivariate analysis and orthogonal partial least square discriminate analysis (OPLS-DA). A complementary Mann-Whitney U test of group difference in individual metabolites was also performed. less thanbrgreater than less thanbrgreater thanA large number of metabolites were detected and identified in this screening study. At baseline, no systematic differences between groups were observed according to the OPLS-DA. However, two metabolites, l-leucine and pyroglutamic acid, were significantly more abundant in the myalgic muscle compared to the healthy muscle. In the recovery period, systematic difference in metabolites between the groups was observed according to the OPLS-DA. The groups differed in amino acids, fatty acids and carbohydrates. Myristic acid and putrescine were significantly more abundant and beta-d-glucopyranose was significantly less abundant in the myalgic muscle. less thanbrgreater than less thanbrgreater thanThis study provides important information regarding the metabolite content, thereby presenting new clues regarding the pathophysiology of the myalgic muscle.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Metabolomics
- Trapezius myalgia
- Microdialysis
- Repetitive work
- Recovery
- GC-MS
- Metabolites
- MEDICINE
- MEDICIN
- anatomi
Publication and Content Type
- ref (subject category)
- art (subject category)
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