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Retinoic acid recep...
Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer
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- Johansson, Henrik J. (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Sanchez, Betzabe C. (author)
- Karolinska Institute, Sweden
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- Mundt, Filip (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Forshed, Jenny (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Kovács, Anikó, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,University Hospital, Sweden
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- Panizza, Elena (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Hultin-Rosenberg, Lina (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Lundgren, Bo (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Science for Life Laboratory (SciLifeLab),Stockholm University, Sweden
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- Martens, Ulf (author)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi,Science for Life Laboratory (SciLifeLab),Stockholm University, Sweden
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- Mathe, Gyongyver (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,University Hospital, Sweden
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- Yakhini, Zohar (author)
- Agilent Labs, Israel Technion Israel Institute Technology, Israel
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- Helou, Khalil, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology,University Hospital, Sweden
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- Krawiec, Kamilla (author)
- Karolinska Institutet,Karolinska Institute, Sweden University Hospital, Sweden
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- Kanter, Lena (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Hjerpe, Anders (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Stål, Olle (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US
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- Linderholm, Barbro, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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- Lehtio, Janne (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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(creator_code:org_t)
- 2013-07-19
- 2013
- English.
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In: Nature Communications. - : Nature Publishing Group: Nature Communications. - 2041-1723. ; 4:3175
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https://www.nature.c...
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Abstract
Subject headings
Close
- About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based proteomics, we show that retinoic acid receptor alpha protein networks and levels differ in a tamoxifen-sensitive (MCF7) and a tamoxifen-resistant (LCC2) cell line. High intratumoural retinoic acid receptor alpha protein levels also correlate with reduced relapse-free survival in oestrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen solely. A similar retinoic acid receptor alpha expression pattern is seen in a comparable independent patient cohort. An oestrogen receptor alpha and retinoic acid receptor alpha ligand screening reveals that tamoxifen-resistant LCC2 cells have increased sensitivity to retinoic acid receptor alpha ligands and are less sensitive to oestrogen receptor alpha ligands compared with MCF7 cells. Our data indicate that retinoic acid receptor alpha may be a novel therapeutic target and a predictive factor for oestrogen receptor alpha-positive breast cancer patients treated with adjuvant tamoxifen.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Henri ...
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Sanchez, Betzabe ...
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Mundt, Filip
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Forshed, Jenny
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Kovács, Anikó, 1 ...
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Panizza, Elena
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show more...
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Hultin-Rosenberg ...
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Lundgren, Bo
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Martens, Ulf
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Mathe, Gyongyver
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Yakhini, Zohar
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Helou, Khalil, 1 ...
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Krawiec, Kamilla
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Kanter, Lena
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Hjerpe, Anders
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Stål, Olle
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Linderholm, Barb ...
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Lehtio, Janne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Nature Communica ...
- By the university
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Linköping University
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University of Gothenburg
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Karolinska Institutet
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Stockholm University