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Tick-borne encephal...
Tick-borne encephalitis virus in ticks detached from humans and follow-up of serological and clinical response.
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- Lindblom, Pontus (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Wilhelmsson, Peter (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Fryland, Linda (author)
- Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet
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- Sjowall, Johanna (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Infektionskliniken i Östergötland
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- Haglund, Mats (author)
- Kalmar County hospital
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- Matussek, Andreas (author)
- County Hospital Ryhov, Jönköping
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- Ernerudh, Jan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
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- Vene, Sirkka (author)
- Swedish Institute for Communicable Disease Control, Stockholm
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- Nyman, Dag (author)
- Åland Central Hospital, Åland, Finland
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- Andreassen, Åshild (author)
- Norwegian Institute of Public Health, Olso, Norway
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- Forsberg, Pia (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,Infektionskliniken i Östergötland
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- Lindgren, Per-Eric (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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(creator_code:org_t)
- Jena, Germany : Elsevier, 2014
- 2014
- English.
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In: Ticks and Tick Borne Diseases. - Jena, Germany : Elsevier. - 1877-959X. ; 5:1, s. 21-28
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Abstract
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- The risk of tick-borne encephalitis virus (TBEV) infection after a tick bite remains largely unknown. To address this, we investigated the presence of TBEV in ticks detached from humans in an attempt to relate viral copy number, TBEV subtype, and tick feeding time with the serological and clinical response of the tick-bitten participants. Ticks, blood samples, and questionnaires were collected from tick-bitten humans at 34 primary health care centers in Sweden and in the Aland Islands (Finland). A total of 2167 ticks was received from 1886 persons in 2008-2009. Using a multiplex quantitative real-time PCR, 5 TBEV-infected ticks were found (overall prevalence 0.23%, copy range <4 X 10(2)-7.7 X 10(6) per tick). One unvaccinated person bitten by a tick containing 7.7 x 10(6) TBEV copies experienced symptoms. Another unvaccinated person bitten by a tick containing 1.8 x 10(3) TBEV copies developed neither symptoms nor TBEV antibodies. The remaining 3 persons were protected by vaccination. In contrast, despite lack of TBEV in the detached ticks, 2 persons developed antibodies against TBEV, one of whom reported symptoms. Overall, a low risk of TBEV infection was observed, and too few persons got bitten by TBEV-infected ticks to draw certain conclusions regarding the clinical outcome in relation to the duration of the blood meal and virus copy number. However, this study indicates that an antibody response may develop without clinical symptoms, that a bite by an infected tick not always leads to an antibody response or clinical symptoms, and a possible correlation between virus load and tick feeding time. (C) 2013 Elsevier GmbH. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lindblom, Pontus
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Wilhelmsson, Pet ...
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Fryland, Linda
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Sjowall, Johanna
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Haglund, Mats
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Matussek, Andrea ...
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show more...
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Ernerudh, Jan
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Vene, Sirkka
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Nyman, Dag
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Andreassen, Åshi ...
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Forsberg, Pia
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Lindgren, Per-Er ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Ticks and Tick B ...
- By the university
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Linköping University