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Reporters of amyloi...
Reporters of amyloid structural polymorphism
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- LeVine III, Harry (author)
- University of Kentucky, Lexington, USA
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- Nilsson, Peter, 1972- (author)
- Linköpings universitet,Kemi,Tekniska högskolan
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- Hammarström, Per, 1970- (author)
- Linköpings universitet,Kemi,Tekniska högskolan
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(creator_code:org_t)
- London : Academic Press, 2014
- 2014
- English.
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In: Bio-nanoimaging. - London : Academic Press. - 9780123944313 ; , s. 69-79
- Related links:
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Abstract
Subject headings
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- Misfolding of proteins induced by environmental conditions or by the presence of destabilizing mutations often triggers squestration (aggresome formation) or cellular removal (unfolded protein response (UPR), autophagy) intracellular responses. Extracellular aggregates are phagocytosed or endocytosed by macrophages in the periphery and microglia and astrocytes in the brain and central nervous system. In some cases a highly stable altemative assembly structure, an amyloid fibril, is formed that is highly resistant to degadation and thus accumulates.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Misfolding
- Proteins
- Amyloid fibrils
Publication and Content Type
- vet (subject category)
- kap (subject category)
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