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Association of STAT...
Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
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- Bolin, Karin (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Sandling, Johanna K (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär medicin,Uppsala University, Sweden Uppsala University, Sweden
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- Zickert, Agneta (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska Institute, Sweden
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Sjöwall, Christoffer (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för inflammationsmedicin,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Svenungsson, Elisabet (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska Institute, Sweden
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- Bengtsson, Anders (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Eloranta, Maija-Leena (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Rönnblom, Lars (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden Uppsala University, Sweden
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden Uppsala University, Sweden
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- Gunnarsson, Iva (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska Institute, Sweden
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- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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(creator_code:org_t)
- 2013-12-27
- 2013
- English.
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In: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 8:12, s. 84450-
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Abstract
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- Lupus nephritis is a cause of significant morbidity in systemic lupus erythematosus (SLE) and its genetic background has not been completely clarified. The aim of this investigation was to analyze single nucleotide polymorphisms (SNPs) for association with lupus nephritis, its severe form proliferative nephritis and renal outcome, in two Swedish cohorts. Cohort I (n = 567 SLE cases, n = 512 controls) was previously genotyped for 5676 SNPs and cohort II (n = 145 SLE cases, n = 619 controls) was genotyped for SNPs in STAT4, IRF5, TNIP1 and BLK. Case-control and case-only association analyses for patients with lupus nephritis, proliferative nephritis and severe renal insufficiency were performed. In the case-control analysis of cohort I, four highly linked SNPs in STAT4 were associated with lupus nephritis with genome wide significance with p = 3.7x10(-9), OR 2.20 for the best SNP rs11889341. Strong signals of association between IRF5 and an HLA-DR3 SNP marker were also detected in the lupus nephritis case versus healthy control analysis (pless than0.0001). An additional six genes showed an association with lupus nephritis with pless than0.001 (PMS2, TNIP1, CARD11, ITGAM, BLK and IRAK1). In the case-only meta-analysis of the two cohorts, the STAT4 SNP rs7582694 was associated with severe renal insufficiency with p = 1.6x10(-3) and OR 2.22. We conclude that genetic variations in STAT4 predispose to lupus nephritis and a worse outcome with severe renal insufficiency.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Bolin, Karin
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Sandling, Johann ...
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Zickert, Agneta
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Jönsen, Andreas
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Sjöwall, Christo ...
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Svenungsson, Eli ...
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Bengtsson, Ander ...
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Eloranta, Maija- ...
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Rönnblom, Lars
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Syvänen, Ann-Chr ...
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Gunnarsson, Iva
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Nordmark, Gunnel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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PLOS ONE
- By the university
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Linköping University
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Lund University
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Uppsala University
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Karolinska Institutet