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Incidence and progn...
Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience
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- Lazarevic, Vladimir (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden
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- Hörstedt, Ann-sofi (author)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden
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- Johansson, Bertil (author)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,University of and Regional Labs Regional Skåne, Sweden Lund University, Sweden
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- Antunovic, Petar (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Department of Hematology, Linköping University Hospital, Linköping, Sweden
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- Billstrom, R. (author)
- Department of Medicine, Central Hospital Skövde, Skövde, Sweden
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- Derolf, A. (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska University Hospital, Sweden
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- Hulegardh, E. (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Lehmann, S. (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska University Hospital, Sweden
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- Mollgard, L. (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Nilsson, C. (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden Karolinska University Hospital, Sweden
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- Peterson, Stefan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden
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- Stockelberg, D. (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Uggla, Bertil, 1962- (author)
- Region Örebro län,Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Wennstrom, L. (author)
- Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden
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- Wahlin, Anders (author)
- Umeå universitet,Onkologi,Umeå University, Sweden
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- Höglund, Martin (author)
- Uppsala universitet,Hematologi,Academic Hospital, Sweden
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- Juliusson, Gunnar (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden Lund University, Sweden
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(creator_code:org_t)
- 2014-02-28
- 2014
- English.
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In: Blood Cancer Journal. - London, United Kingdom : Nature Publishing Group: Open Access Journals - Option B / Nature Publishing Group. - 2044-5385. ; 4:e188
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Abstract
Subject headings
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- The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8; 21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with greater than= 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients less than80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both Pless than0.001), followed by sex (P = 0.0135) and a karyotype including - 7/del(7q) (P = 0.048).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lazarevic, Vladi ...
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Hörstedt, Ann-so ...
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Johansson, Berti ...
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Antunovic, Petar
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Billstrom, R.
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Derolf, A.
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show more...
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Hulegardh, E.
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Lehmann, S.
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Mollgard, L.
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Nilsson, C.
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Peterson, Stefan
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Stockelberg, D.
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Uggla, Bertil, 1 ...
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Wennstrom, L.
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Wahlin, Anders
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Höglund, Martin
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Juliusson, Gunna ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Blood Cancer Jou ...
- By the university
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Linköping University
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Örebro University
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University