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Microcirculation as...
Microcirculation assessment using an individualized model for diffuse reflectance spectroscopy and conventional laser Doppler flowmetry
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- Strömberg, Tomas (author)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
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- Karlsson, Hanna (author)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
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- Fredriksson, Ingemar (author)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan,Perimed AB, Järfälla, Sweden
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- Nyström, Fredrik H. (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Endokrinmedicinska kliniken,Avdelningen för kardiovaskulär medicin
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- Larsson, Marcus (author)
- Linköpings universitet,Institutionen för medicinsk teknik,Tekniska högskolan
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(creator_code:org_t)
- SPIE - International Society for Optical Engineering, 2014
- 2014
- English.
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In: Journal of Biomedical Optics. - : SPIE - International Society for Optical Engineering. - 1083-3668 .- 1560-2281. ; 19:5, s. 057002-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Microvascular assessment would benefit from co-registration of blood flow and hemoglobin oxygenation dynamics during stimulus response tests. We used a fiber-optic probe for simultaneous recording of white light diffuse reflectance (DRS; 475-850 nm) and laser Doppler flowmetry (LDF; 780 nm) spectra at two source-detector distances (0.4 and 1.2 mm). An inverse Monte Carlo algorithm, based on a multiparameter three-layer adaptive skin model, was used for analyzing DRS data. LDF spectra were conventionally processed for perfusion. The system was evaluated on volar forearm recordings of 33 healthy subjects during a 5-min systolic occlusion protocol. The calibration scheme and the optimal adaptive skin model fitted DRS spectra at both distances within 10%. During occlusion, perfusion decreased within 5 s while oxygenation decreased slowly (mean time constant 61 s; dissociation of oxygen from hemoglobin). After occlusion release, perfusion and oxygenation increased within 3 s (inflow of oxygenized blood). The increased perfusion was due to increased blood tissue fraction and speed. The supranormal hemoglobin oxygenation indicates a blood flow in excess of metabolic demands. In conclusion, by integrating DRS and LDF in a fiber-optic probe, a powerful tool for assessment of blood flow and oxygenation in the same microvascular bed has been presented.
Publication and Content Type
- ref (subject category)
- art (subject category)
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