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Proinsulin and IGFBP-1 predicts mortality in an elderly population
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- Chisalita, Ioana Simona (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Akutkliniken
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- Dahlström, Ulf (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US
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- Arnqvist, Hans (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Endokrinmedicinska kliniken
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- (creator_code:org_t)
- Elsevier, 2014
- 2014
- English.
- In: International Journal of Cardiology. - : Elsevier. - 0167-5273 .- 1874-1754. ; 174:2, s. 260-267
- Journal article (peer-reviewed)
Abstract
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- BACKGROUND:High IGFBP-1 in elderly subjects is related to all-cause and cardiovascular (CV) mortality. We studied the relation of IGFBP-1 to cardiometabolic risk factors and cardiovascular and all-cause mortality, and also the impact of proinsulin and insulin on this association in an unselected elderly primary health care population.HYPOTHESIS:Our hypothesis was that proinsulin and insulin may have an impact on the association of high IGFBP-1 levels with all-cause and CV-mortality in elderly.DESIGN, SETTING AND PARTICIPANTS:A cross-sectional and prospective study was carried out in a rural Swedish population. 851 persons aged 66-81 years were evaluated by medical history, clinical examination, electrocardiography, echocardiography, and fasting plasma samples, and were followed prospectively for up to 12 years.RESULTS:At baseline, in a multivariate analysis, IGFBP-1 was associated with gender, N-terminal proBNP (NT pro-BNP), blood glucose, body mass index (BMI), insulin and proinsulin, estimated glomerular filtration rate (eGFR) and haemoglobin (Hb). During the follow-up period there were 230 deaths (27%), of which 134 (16%) were due to CV mortality. When divided into tertiles there was a significant difference for CV mortality and all-cause mortality between tertiles of IGFBP-1 and proinsulin. For insulin there was a significant difference only for all-cause mortality. After adjustment for well-known risks factors, proinsulin and IGFBP-1 had significant impact on all-cause mortality but only proinsulin on CV mortality.CONCLUSION:Only proinsulin is an independent predictor for both all-cause mortality and CV mortality when comparing IGFBP-1, insulin, and proinsulin as prognostic biomarkers for CV and all-cause mortality in an elderly population.
Keyword
- Insulin-like growth factor binding protein-1
- Proinsulin
- Insulin
- Elderly population
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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