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Proinsulin and IGFB...
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Chisalita, Ioana SimonaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Akutkliniken
(author)
Proinsulin and IGFBP-1 predicts mortality in an elderly population
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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Elsevier,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-108157
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108157URI
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https://doi.org/10.1016/j.ijcard.2014.03.171DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND:High IGFBP-1 in elderly subjects is related to all-cause and cardiovascular (CV) mortality. We studied the relation of IGFBP-1 to cardiometabolic risk factors and cardiovascular and all-cause mortality, and also the impact of proinsulin and insulin on this association in an unselected elderly primary health care population.HYPOTHESIS:Our hypothesis was that proinsulin and insulin may have an impact on the association of high IGFBP-1 levels with all-cause and CV-mortality in elderly.DESIGN, SETTING AND PARTICIPANTS:A cross-sectional and prospective study was carried out in a rural Swedish population. 851 persons aged 66-81 years were evaluated by medical history, clinical examination, electrocardiography, echocardiography, and fasting plasma samples, and were followed prospectively for up to 12 years.RESULTS:At baseline, in a multivariate analysis, IGFBP-1 was associated with gender, N-terminal proBNP (NT pro-BNP), blood glucose, body mass index (BMI), insulin and proinsulin, estimated glomerular filtration rate (eGFR) and haemoglobin (Hb). During the follow-up period there were 230 deaths (27%), of which 134 (16%) were due to CV mortality. When divided into tertiles there was a significant difference for CV mortality and all-cause mortality between tertiles of IGFBP-1 and proinsulin. For insulin there was a significant difference only for all-cause mortality. After adjustment for well-known risks factors, proinsulin and IGFBP-1 had significant impact on all-cause mortality but only proinsulin on CV mortality.CONCLUSION:Only proinsulin is an independent predictor for both all-cause mortality and CV mortality when comparing IGFBP-1, insulin, and proinsulin as prognostic biomarkers for CV and all-cause mortality in an elderly population.
Subject headings and genre
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Insulin-like growth factor binding protein-1
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Proinsulin
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Insulin
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Elderly population
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Dahlström, UlfÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)ulfda85
(author)
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Arnqvist, HansÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Endokrinmedicinska kliniken(Swepub:liu)hanar64
(author)
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Alehagen, UrbanÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)urbal84
(author)
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Linköpings universitetAvdelningen för cellbiologi
(creator_code:org_t)
Related titles
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In:International Journal of Cardiology: Elsevier174:2, s. 260-2670167-52731874-1754
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