Apoptins: selective anticancer agents

Rollano Penaloza, Oscar M.Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Instituto de Biologia Molecular y Biotecnologia, La Paz, Bolivia (author)

Apoptins : selective anticancer agents

Therapies that selectively target cancer cells for deathhave been the center of intense research recently. Onepotential therapy may involve apoptin proteins, whichare able to induce apoptosis in cancer cells leavingnormal cells unharmed. Apoptin was originally discoveredin the Chicken anemia virus (CAV); however, humangyroviruses (HGyV) have recently been found that alsoharbor apoptin-like proteins. Although the cancer cellspecific activity of these apoptins appears to be wellconserved, the precise functions and mechanisms ofaction are yet to be fully elucidated. Strategies for bothdelivering apoptin to treat tumors and disseminating theprotein inside the tumor body are now being developed,and have shown promise in preclinical animal studies.

Lewandowska, MagdalenaPomeranian Medical University, Szczecin, Poland (author)
Stetefeld, JoergUniversity of Manitoba, Winnipeg, Canada (author)
Ossysek, KarolinaJagiellonian University, Krakow, Poland (author)
Madej, MariuszJagiellonian University, Krakow, Poland (author)
Bereta, JoannaJagiellonian University, Krakow, Poland (author)
Sobczak, MateuszJagiellonian University, Krakow, Poland (author)
Shojaei, ShahlaShiraz University of Medical Sciences, Iran (author)
Ghavami, SaeidUniversity of Manitoba, Winnipeg, Canada and Shiraz University of Medical Sciences, Iran (author)
Los, Marek JanLinköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet,Pomeranian Medical University, Szczecin, Poland(Swepub:liu)marlo14 (author)
Linköpings universitetAvdelningen för cellbiologi (creator_code:org_t)

By the author/editor: Rollano Penaloza ...; Lewandowska, Mag ...; Stetefeld, Joerg; Ossysek, Karolin ...; Madej, Mariusz; Bereta, Joanna; show more...; Sobczak, Mateusz; Shojaei, Shahla; Ghavami, Saeid; Los, Marek Jan; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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