onr:"swepub:oai:DiVA.org:liu-110970"
Search: onr:"swepub:oai:DiVA.org:liu-110970" > Overexpression of M...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Jönsson, SimonLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet (author)
Overexpression of MMP-9 and Its Inhibitors in Blood Mononuclear Cells after Myocardial Infarction - Is It Associated with Depressive Symptomatology?
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- 2014-08-25
- Public Library of Science,2014
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-110970
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110970URI
- https://doi.org/10.1371/journal.pone.0105572DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Funding Agencies|Swedish Research Council [521-2011-3847]; Swedish Heart-Lung Foundation [20120608]
- Background: Matrix metalloproteinase (MMP)-9 may play a central role in the development and progression of atherosclerosis. Emerging evidence also indicates an association between MMP-9 and depressive symptomatology. Here, we investigated whether expression of MMP-9 and its inhibitors in blood mononuclear cells and plasma were related to depressive symptoms in patients with a recent myocardial infarction (MI). Methods and Results: Blood sampling was performed between 6 and 18 months after MI in 57 patients. Forty-one clinically healthy subjects were included as controls. Gene expression of MMP-9 and its main tissue inhibitors TIMP-1 and -2 were analyzed in freshly isolated or cultured blood mononuclear cells. Corresponding protein levels were assessed in cell supernatants and plasma. In post-MI patients, mRNA levels of MMP-9 and TIMP-1 and -2 were significantly higher than in controls while protein levels in cell supernatants and plasma did not differ between groups. The Center for Epidemiological Studies - Depression (CES-D) scale was used to assess depressive symptomatology. Repeated assessments during the first 18 months after MI showed significantly higher CES-D scores in patients compared with controls. However, there were no relationships between depressive mood and any of the measurements of MMP-9 or TIMPs. Conclusion: Our findings indicate that overexpression of MMP-9 and TIMPs in blood mononuclear cells and elevated depressive symptoms represent two unrelated phenomena after MI.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Lundberg, AnnaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet(Swepub:liu)annli40 (author)
- Jonasson, LenaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Kardiologiska kliniken US(Swepub:liu)lenjo59 (author)
- Linköpings universitetAvdelningen för kardiovaskulär medicin (creator_code:org_t)
Related titles
- In:PLOS ONE: Public Library of Science9:8, s. e105572-1932-6203
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Jönsson, Simon
- Lundberg, Anna
- Jonasson, Lena
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- Articles in the publication
- PLOS ONE
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
