Synergic post-antibiotic effect of amikacin in combination with beta-lactam antibiotics on gram-negative bacteria.

Isaksson, Barbro (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet

Hanberger, Håkan (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet

Maller, Rolf (author): Linköpings universitet,Infektionsmedicin,Hälsouniversitetet

Nilsson, Lennart E (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet

Nilsson, Maud (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet

(creator_code:org_t)

Oxford University Press, 1991
1991
English.
In: Journal of Antimicrobial Chemotherapy. - : Oxford University Press. - 0305-7453 .- 1460-2091. ; 28:1, s. 25-34

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

The post-antibiotic effect (PAE) of amikacin alone and in combination with ceftazidime, ceftriaxone and piperacillin was studied for two strains each of Pseudomonas aeruginosa and Serratia marcescens using a bioluminescent assay of bacterial ATP. Two models were used for combining beta-lactam antibiotics and amikacin: in one model the cultures were incubated with 32 mg/L of ceftazidime, 128 mg/L of ceftriaxone or 32 mg/L of piperacillin for 1 h. Different concentrations of amikacin (0.5-64 mg/L) were then added. Incubation of the combinations continued for one more hour. The antibiotics were eliminated by dilution. In the second model tested, one strain of S. marcescens was simultaneously exposed to amikacin and a beta-lactam antibiotic for 2 h. The PAEs produced by the drugs in combination were longer than the sum of the individual effects of the drugs when they were used alone. Results were equally good with both models. A synergic PAE was also found with amikacin concentrations close to the MIC in combination with low concentrations of ceftazidime, ceftriaxone and piperacillin.

By the author/editor: Isaksson, Barbro; Hanberger, Håkan; Maller, Rolf; Nilsson, Lennart ...; Nilsson, Maud

About the subject

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