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Potential benefit o...
Potential benefit of scanned proton beam versus photons as adjuvant radiation therapy in breast cancer
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- Flejmer, Anna M. (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Witt Nyström, Petra (author)
- Uppsala University Hospital
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- Dohlmar, Frida (author)
- Linköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Hälsouniversitetet,Avdelningen för radiologiska vetenskaper
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- Josefsson, Dan (author)
- Linköpings universitet,Hälsouniversitetet,Avdelningen för radiologiska vetenskaper,Region Östergötland, Radiofysikavdelningen US
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- Dasu, Alexandru (author)
- Linköpings universitet,Östergötlands Läns Landsting,Radiofysikavdelningen US,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: International Journal of Particle Therapy. - 2331-5180. ; 1:4, s. 845-855
- Related links:
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https://doi.org/10.1...
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http://theijpt.org/d...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Purpose: To investigate the feasibility of using scanned proton beams as adjuvant radiation therapy for breast cancer. Long-term cardiopulmonary complications may worsen the quality of life and reduce the positive contribution of radiation therapy, which has been known to improve long-term control of locoregional disease as well as the long-term survival for these patients.Materials and Methods: Ten patients with stage I-III cancer (either after mastectomy or lumpectomy, left- or right-sided) were included in the study. The patients were identified from a larger group where dose heterogeneity in the target and/or hotspots in the normal tissues qualified them for irregular surface compensator planning with photons. The patients underwent planning with 2 scanned proton beam planning techniques, single-field uniform dose and intensity-modulated proton therapy, and the results were compared with those from irregular surface compensator. All volumes of interest were delineated and reviewed by experienced radio-oncologists. The patients were prescribed 50 GyRBE in 25 fractions. Dosimetric parameters of interest were compared with a paired, 2-tailed Student t test.Results: The proton plans showed comparable or better target coverage than the original photon plans. There were also large reductions with protons in mean doses to the heart (0.2 versus 1.3 GyRBE), left anterior descending artery (1.4 versus 6.4 GyRBE), and the ipsilateral lung (6.3 versus 7.7 GyRBE). This reduction is important from the point of view of the quality of life of the patients after radiation therapy. No significant differences were found between single-field uniform dose and intensity-modulated proton therapy plans.Conclusion: Spot scanning technique with protons may improve target dose homogeneity and further reduce doses to the organs at risk compared with advanced photon techniques. The results from this study indicate a potential for protons as adjuvant radiation therapy in breast cancer and a further step toward the individualization of treatment based on anatomic and comorbidity characteristics.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- breast radiation therapy
- proton radiation therapy
- pencil beam scanning
- irregular surface compensator
- fractionated radiation therapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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