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The cerebrospinal f...
The cerebrospinal fluid "Alzheimer profile": Easily said, but what does it mean?
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- Duits, Flora H. (author)
- Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands,University of Paris 06, France; University of Paris 06, France
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- Teunissen, Charlotte E. (author)
- Vrije University of Amsterdam, Netherlands
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- Bouwman, Femke H. (author)
- Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands
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- Visser, Pieter-Jelle (author)
- Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands; University of Maastricht, Netherlands
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- Mattsson, Niklas, 1979 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre Imaging Neurodegenerat Disease, CA USA
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,UCL Institute Neurol, England
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg, Sweden
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Sweden
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Lund University, Sweden
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- Andreasen, Niels (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Marcusson, Jan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Geriatriska kliniken,Vrije University of Amsterdam, Netherlands
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- Wallin, Anders, 1950 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University of Gothenburg, Sweden
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- Olde Rikkert, Marcel (author)
- Donders Institute Brain Cognit and Behav, Netherlands
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- Tsolaki, Magda (author)
- Aristotle University of Thessaloniki, Greece
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- Parnetti, Lucilla (author)
- University of Perugia, Italy
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- Herukka, Sanna-Kaisa (author)
- University of Eastern Finland, Finland; Kuopio University Hospital, Finland
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- Hampel, Harald (author)
- University of Paris 06, France; University of Paris 06, France
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- De Leon, Mony J. (author)
- NYU, NY USA
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- Schroeder, Johannes (author)
- Heidelberg University, Germany
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- Aarsland, Dag (author)
- Karolinska Institutet,Stavanger University Hospital, Norway
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- Blankenstein, Marinus A. (author)
- Vrije University of Amsterdam, Netherlands
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- Scheltens, Philip (author)
- Vrije University of Amsterdam, Netherlands; Vrije University of Amsterdam, Netherlands
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- van der Flier, Wiesje M. (author)
- Vrije University of Amsterdam, Netherlands
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(creator_code:org_t)
- 2014-04-09
- 2014
- English.
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In: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 10:6, s. 713-723
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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http://kipublication...
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Abstract
Subject headings
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- Background: We aimed to identify the most useful definition of the "cerebrospinal fluid Alzheimer profile," based on amyloid-beta(1-42) (A beta(42)), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimers disease (AD). Methods: We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results: Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/A beta(42) ratio and 0.08 for the p-tau/A beta(42) ratio. Ratios performed similar to formulas (sensitivity, 91%-93%; specificity, 81%-84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/A beta(42) ratio. Conclusions: A tau/A beta(42) ratio of greater than0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Dementia; Alzheimers disease; Mild cognitive impairment; Cerebrospinal fluid; Amyloid-beta(1-42); Tau; Biomarkers; Differential diagnosis; Predictive value
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Duits, Flora H.
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Teunissen, Charl ...
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Bouwman, Femke H ...
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Visser, Pieter-J ...
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Mattsson, Niklas ...
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Zetterberg, Henr ...
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show more...
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Blennow, Kaj, 19 ...
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Hansson, Oskar
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Minthon, Lennart
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Andreasen, Niels
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Marcusson, Jan
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Wallin, Anders, ...
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Olde Rikkert, Ma ...
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Tsolaki, Magda
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Parnetti, Lucill ...
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Herukka, Sanna-K ...
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Hampel, Harald
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De Leon, Mony J.
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Schroeder, Johan ...
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Aarsland, Dag
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Blankenstein, Ma ...
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Scheltens, Phili ...
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van der Flier, W ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Linköping University
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Lund University
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University of Gothenburg
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Karolinska Institutet