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Targeted delivery o...
Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect
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- Senthilkumar, Rajendran (author)
- Abo Akad University, Finland
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- Sen Karaman, Didem (author)
- Abo Akad University, Finland
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- Paul, Preethy (author)
- Abo Akad University, Finland
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- Johansson, Emma (author)
- Linköpings universitet,Nanostrukturerade material,Tekniska högskolan
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- Odén, Magnus (author)
- Linköpings universitet,Nanostrukturerade material,Tekniska högskolan
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- Eriksson, John E. (author)
- Abo Akad University, Finland
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- Rosenholm, Jessica M. (author)
- Abo Akad University, Finland
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(creator_code:org_t)
- 2015
- 2015
- English.
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In: BIOMATERIALS SCIENCE. - : Royal Society of Chemistry. - 2047-4830 .- 2047-4849. ; 3:1, s. 103-111
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https://liu.diva-por... (primary) (Raw object)
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Targeted cancer therapies are currently a strong focus in biomedical research. The most common approach is to use nanocarrier-based targeting to specifically deliver conventional anticancer drugs to enhance their therapeutic efficacy, increase bioavailability, and decrease the side-effects on normal cells. A step further towards higher specificity and efficacy would be to employ specific novel drugs along with specific nanocarrier-based targeting. Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP). The cellular internalization and uptake enhancement of the FA-Chitosan-NR-MSP towards cancerous folate receptor (FR)-positive (SiHa and HeLa) and/or normal FR-negative (HEK 293) cells were assessed, which indicated that the intracellular uptake of FA-conjugated Chitosan-NR-MSP was more target-specific. Furthermore, the induction of apoptosis by AA-loaded chitosan-coated rod-shaped particles on SiHa cells was studied. By employing caspase-3 activation and PARP cleavage as measure of apoptosis, the FA-particle mediated AA treatment was clearly more effective, significantly enhancing apoptosis in comparison to non-targeted Chitosan-NR-MSP or free AA in SiHa cells, suggesting that the FA-Chitosan-NR-MSPs can be potentially utilized as a drug delivery system for cervical cancer treatment.
Subject headings
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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