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The cost-effectiven...
The cost-effectiveness of radiofrequency catheter ablation as first-line treatment for paroxysmal atrial fibrillation : results from a MANTRA-PAF substudy.
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- Aronsson, Mattias (author)
- Linköpings universitet,Avdelningen för hälso- och sjukvårdsanalys,Medicinska fakulteten
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- Walfridsson, Håkan (author)
- Linköpings universitet,Östergötlands Läns Landsting,Kardiologiska kliniken US,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten
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- Janzon, Magnus (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Walfridsson, Ulla (author)
- Linköpings universitet,Avdelningen för omvårdnad,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Nielsen, Jens Cosedis (author)
- Aarhus University Hospital, Denmark
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- Hansen, Peter Steen (author)
- Aarhus University Hospital, Denmark
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- Johannessen, Arne (author)
- Gentofte University Hospital, Denmark
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- Raatikainen, Pekka (author)
- Tampere University Hospital, Finland
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- Hindricks, Gerhard (author)
- Leipzig University Hospital, Germany
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- Kongstad Rasmussen, Ole (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital, Sweden
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- Pehrson, Steen (author)
- Rigshospitalet, Denmark
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- Englund, Anders (author)
- University Hospital, Örebro, Sweden
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- Hartikainen, Juha (author)
- Kuopio University Hospital, Finland
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- Mortensen, Leif Spange (author)
- Danish Information Technology Centre for Education and Research, Aarhus, Denmark
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- Levin, Lars-Åke (author)
- Linköpings universitet,Avdelningen för hälso- och sjukvårdsanalys,Medicinska fakulteten
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(creator_code:org_t)
- 2014-10-23
- 2015
- English.
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In: Europace. - : Oxford University Press (OUP). - 1099-5129 .- 1532-2092. ; 17:1, s. 48-55
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Abstract
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- AIM: The aim of this prospective substudy was to estimate the cost-effectiveness of treating paroxysmal atrial fibrillation (AF) with radiofrequency catheter ablation (RFA) compared with antiarrhythmic drugs (AADs) as first-line treatment.METHODS AND RESULTS: A decision-analytic Markov model, based on MANTRA-PAF (Medical Antiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation) study data, was developed to study long-term effects and costs of RFA compared with AADs as first-line treatment. Positive clinical effects were found in the overall population, a gain of an average 0.06 quality-adjusted life years (QALYs) to an incremental cost of €3033, resulting in an incremental cost-effectiveness ratio of €50 570/QALY. However, the result of the subgroup analyses showed that RFA was less costly and more effective in younger patients. This implied an incremental cost-effectiveness ratio of €3434/QALY in ≤50-year-old patients respectively €108 937/QALY in >50-year-old patients.CONCLUSION: Radiofrequency catheter ablation as first-line treatment is a cost-effective strategy for younger patients with paroxysmal AF. However, the cost-effectiveness of using RFA as first-line therapy in older patients is uncertain, and in most of these AADs should be attempted before RFA (MANTRA-PAF ClinicalTrials.gov number; NCT00133211).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- ref (subject category)
- art (subject category)
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Aronsson, Mattia ...
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Walfridsson, Håk ...
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Janzon, Magnus
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Walfridsson, Ull ...
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Nielsen, Jens Co ...
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Hansen, Peter St ...
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Johannessen, Arn ...
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Raatikainen, Pek ...
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Hindricks, Gerha ...
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Kongstad Rasmuss ...
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Pehrson, Steen
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Englund, Anders
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Hartikainen, Juh ...
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Mortensen, Leif ...
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Levin, Lars-Åke
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Europace
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Linköping University
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Lund University