Association of serum antibodies against defined epitopes of human papillomavirus L1, E2, and E7 antigens and of HPV DNA with incident cervical cancer.

Zellbi, A (author)

Åvall-Lundqvist, Elisabeth (author): Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Department of Gynecologic Oncology, Karolinska Hospital, Stockholm, Sweden

Heino, P (author)

Eklund, C (author)

Pettersson, C A (author)

Forslund, O (author)

Hansson, B G (author)

Grandien, M (author)

Bistoletti, P (author)

(creator_code:org_t)

1995
1995
English.
In: Cancer Detection and Prevention. - 0361-090X .- 1873-443X. ; 19:5, s. 381-93

Related links:: https://urn.kb.se/re...; show more...; http://kipublication...; show less...

Abstract Subject headings

In order to provide a large-scale evaluation of the association with cervical cancer of antibodies against human papillomavirus (HPV) antigens, sera from 233 patients with primary, untreated cervical cancer and from 157 healthy age- and sex-matched blood donors were analyzed for IgG and IgA antibodies against HPV-derived peptide antigens and against bovine papillomavirus. Several serological responses were strongly associated with cervical cancer, notably the IgG response against the HPV 16 epitopes L1:13 (Relative risk [RR]: 5.3), E2:9 (RR: 2.9), and E7:5 (RR: 4.3), and the IgA response against an HPV 18 E2-derived antigen (245:18, RR: 3.1). HPV DNA in corresponding cervical tumors was analyzed by Southern blotting (SB) and polymerase chain reaction (PCR) in 47 patients. Sixty-six percent of the patients carried HPV DNA as determined by SB, 91% of patients analyzed by PCR. Neither the antibody responses, nor the presence of HPV DNA were significantly associated with the biological properties of the tumors.

By the author/editor: Dillner, L; Zellbi, A; Åvall-Lundqvist, ...; Heino, P; Eklund, C; Pettersson, C A; show more...; Forslund, O; Hansson, B G; Grandien, M; Bistoletti, P; show less...

About the subject

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