Search: onr:"swepub:oai:DiVA.org:liu-113901" >
Association of seru...
Association of serum antibodies against defined epitopes of human papillomavirus L1, E2, and E7 antigens and of HPV DNA with incident cervical cancer.
-
- Dillner, L (author)
- Karolinska Institutet
-
Zellbi, A (author)
-
- Åvall-Lundqvist, Elisabeth (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Department of Gynecologic Oncology, Karolinska Hospital, Stockholm, Sweden
-
show more...
-
Heino, P (author)
-
Eklund, C (author)
-
Pettersson, C A (author)
-
Forslund, O (author)
-
Hansson, B G (author)
-
Grandien, M (author)
-
Bistoletti, P (author)
-
show less...
-
(creator_code:org_t)
- 1995
- 1995
- English.
-
In: Cancer Detection and Prevention. - 0361-090X .- 1873-443X. ; 19:5, s. 381-93
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- In order to provide a large-scale evaluation of the association with cervical cancer of antibodies against human papillomavirus (HPV) antigens, sera from 233 patients with primary, untreated cervical cancer and from 157 healthy age- and sex-matched blood donors were analyzed for IgG and IgA antibodies against HPV-derived peptide antigens and against bovine papillomavirus. Several serological responses were strongly associated with cervical cancer, notably the IgG response against the HPV 16 epitopes L1:13 (Relative risk [RR]: 5.3), E2:9 (RR: 2.9), and E7:5 (RR: 4.3), and the IgA response against an HPV 18 E2-derived antigen (245:18, RR: 3.1). HPV DNA in corresponding cervical tumors was analyzed by Southern blotting (SB) and polymerase chain reaction (PCR) in 47 patients. Sixty-six percent of the patients carried HPV DNA as determined by SB, 91% of patients analyzed by PCR. Neither the antibody responses, nor the presence of HPV DNA were significantly associated with the biological properties of the tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dillner, L
-
Zellbi, A
-
Åvall-Lundqvist, ...
-
Heino, P
-
Eklund, C
-
Pettersson, C A
-
show more...
-
Forslund, O
-
Hansson, B G
-
Grandien, M
-
Bistoletti, P
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Cancer Detection ...
- By the university
-
Linköping University
-
Karolinska Institutet