onr:"swepub:oai:DiVA.org:liu-114161"
Search: onr:"swepub:oai:DiVA.org:liu-114161" > Disordered methioni...
- 1 of 1
- Previous record
- Next record
- To hitlist
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology
-
- Dudman, N. P. B. (author)
- Department of Medicine, University of New South Wales, Prince Henry Hospital, Uttle Bay, UK
-
- Wilcken, D. E. (author)
- Department of Medicine, University of New South Wales, Prince Henry Hospital, Uttle Bay, UK
-
- Wang, J. (author)
- Department of Medicine, University of New South Wales, Prince Henry Hospital, Uttle Bay, UK
- show more...
- show less...
- (creator_code:org_t)
- American Heart Association, 1993
- 1993
- English.
- In: Arteriosclerosis, Thrombosis and Vascular Biology. - : American Heart Association. - 1079-5642 .- 1524-4636. ; 13:9, s. 1253-1260
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Mild homocysteinemia occurs surprisingly often in patients with premature vascular disease. We studied the possible enzymatic sources of this mild hyperhomocysteinemia and the control of homocysteine levels in plasma by treatment of patients with the cofactors and cosubstrates of homocysteine catabolism. We assessed homocysteine metabolism in 131 patients who had premature disease in their coronary, peripheral, or cerebrovascular circulation by using a standard oral methionine-load test. Impaired homocysteine metabolism occurred in 28 patients. We assayed levels of the primary enzymes of homocysteine catabolism in cultured skin fibroblast extracts from 15 of these 28 patients. The patients' cystathionine beta-synthase levels (3.68 +/- 2.52 nmol/h per milligram of cell protein, mean +/- SD) were markedly depressed compared with those from 31 healthy adult control subjects (7.61 +/- 4.49, P < .001). The patients' levels of 5-methyltetrahydrofolate: homocysteine methyltransferase were normal. While betaine: homocysteine methyltransferase was not expressed in skin fibroblasts, 24-hour urinary betaine and N,N-dimethylglycine measurements were consistent with normal or enhanced remethylation of homocysteine by betaine: homocysteine methyltransferase in the 13 patients tested. When treated daily with choline and betaine, pyridoxine, or folic acid, there was a normalization of the postmethionine plasma homocysteine level in 16 of 19 patients. Our results indicate that mild homocysteinemia in premature vascular disease may be caused by either a folate deficiency or deficiencies in cystathionine beta-synthase activity. It does not necessarily involve deficiencies of either 5-methyltetrahydrofolate:homocysteine methyltransferase or betaine:homocysteine methyltransferase. Effective treatment regimens are also defined.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Keyword
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/metabolism
- Adolescent
- Adult
- Aged
- Betaine-Homocysteine S-Methyltransferase
- Cerebrovascular Disorders/*metabolism
- Coronary Disease/drug therapy/*metabolism
- Cystathionine beta-Synthase/metabolism
- Female
- Homocysteine/*metabolism
- Humans
- Male
- Methionine/*metabolism
- Methyltransferases/metabolism
- Middle Aged
- Peripheral Vascular Diseases/*metabolism
- Vitamins/therapeutic use
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Arteriosclerosis, Thrombosis and Vascular Biology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Dudman, N. P. B.
- Wilcken, D. E.
- Wang, J.
- Lynch, J. F.
- Macey, D.
- Lundberg, Peter
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Chemical Science ...
- and Physical Chemist ...
- Articles in the publication
- Arteriosclerosis ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
