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Severe infusion-rel...
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Norin, StefanKarolinska Institutet
(author)
Severe infusion-related reactions are uncommon in rituximab-treated CLL patients in clinical practice: Results from a Swedish national observational study
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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Elsevier,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-114250
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114250URI
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https://doi.org/10.1016/j.leukres.2014.09.019DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130480623URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Roche Sweden AB [ML22754]
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There have been concerns about serious infusion-related adverse drug reactions (ADR) with rituximabin chronic lymphocytic leukemia (CLL). We therefore conducted an observational trial in which CLL patients planned for rituximab-containing therapy were eligible. Ninety-six patients from 19 centers were enrolled. The most common regimen was rituximab, fludarabine and cyclophosphamide. Fifty-six patients experienced ADR during rituximab infusion. Reactions greater than= grade 3 occurred in five patients and no cases of tumor lysis syndrome were recorded. Despite a high number of circulating tumor cells few severe ADR were noted. Thus, rituximab containing regimens can be considered safe for CLL patients in general practice.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Bjorkstrand, BoKarolinska University Hospital, Sweden; Karolinska Institute, Sweden
(author)
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Rommel, FranzRegion Östergötland, Hematologiska kliniken US
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Timberg, LarsKristianstad Central Hospital, Sweden
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Andersson, Per-OlaSahlgrens University Hospital, Sweden
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Haggstrom, JohanKalmar Hospital, Sweden
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Aldrin, AndersVisby Hospital, Sweden
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Hansson, LottaKarolinska Institutet
(author)
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Karolinska InstitutetKarolinska University Hospital, Sweden; Karolinska Institute, Sweden
(creator_code:org_t)
Related titles
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In:Leukemia Research: Elsevier39:1, s. 33-370145-21261873-5835
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