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Quantitative Assess...
Quantitative Assessment of Turbulence and Flow Eccentricity in an Aortic Coarctation - Impact of Virtual Interventions
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- Andersson, Magnus, 1983- (author)
- Linköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska högskolan
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- Lantz, Jonas (author)
- Linköpings universitet,Medie- och Informationsteknik,Tekniska högskolan
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- Ebbers, Tino (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Fysiologiska kliniken US
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- Karlsson, Matts (author)
- Linköpings universitet,Mekanisk värmeteori och strömningslära,Tekniska högskolan,Centrum för medicinsk bildvetenskap och visualisering, CMIV
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(creator_code:org_t)
- 2015-03-03
- 2015
- English.
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In: Cardiovascular Engineering and Technology. - : Springer. - 1869-408X .- 1869-4098. ; 6:6, s. 281-293
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Turbulence and flow eccentricity can be measured by magnetic resonance imaging (MRI) and may play an important role in the pathogenesis of numerous cardiovascular diseases. In the present study, we propose quantitative techniques to assess turbulent kinetic energy (TKE) and flow eccentricity that could assist in the evaluation and treatment of stenotic severities. These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. Patient-specific geometry and flow conditions were derived from MRI data. The unsteady pulsatile flow was resolved by large eddy simulation (LES) including non-Newtonian blood rheology. Results showed an inverse asymptotic relationship between the total amount of TKE and degree of dilatation of the stenosis, where turbulent flow proximal the constriction limits the possible improvement by treating the CoA alone. Spatiotemporal maps of TKE and flow eccentricity could be linked to the characteristics of the jet, where improved flow conditions were favored by an eccentric dilatation of the CoA. By including these flow markers into a combined MRI-CFD intervention framework, CoA therapy has not only the possibility to produce predictions via simulation, but can also be validated pre- and immediate post treatment, as well as during follow-up studies.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Teknisk mekanik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Applied Mechanics (hsv//eng)
Keyword
- Computational fluid dynamics
- Large eddy simulation
- Turbulent kinetic energy
- Flow displacement
- Non-Newtonian
- Virtual treatment
- Magnetic resonance imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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