The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres

Saint-Leger, A. (author): Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France; Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France

Koelblen, M. (author): Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France

Civitelli, Livia (author)

Bah, A. (author): Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France; Institute of Biochemistry (IBC), Eidgenössische Technische Hochschule Zürich (ETHZ), Zürich, Switzerland

Djerbi, N. (author): Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France

Giraud-Panis, M.-J. (author): Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France; Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France

Londono-Vallejo, A. (author): Telomeres and Cancer Lab., UMR3244, Institut Curie, Paris, France

Ascenzioni, F. (author): Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biologia e Biotecnologie Charles Darwin, Sapienza Università di Roma, Rome, Italy

Gilson, E. (author): Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR7284/INSERM U1081, Faculty of Medicine, Nice, France; Laboratoire de Biologie Moléculaire de la Cellule, CNRS UMR5239, Ecole Normale Supérieure de Lyon, Lyon, France; Department of Medical Genetics, Archet 2 Hospital, CHU of Nice, Nice, France

(creator_code:org_t)

2014-06-26
2014
English.
In: Cell Cycle. - : Taylor andamp; Francis: STM, Behavioural Science and Public Health Titles. - 1538-4101 .- 1551-4005. ; 13:15, s. 2469-2479

Related links:: https://www.tandfonl...; show more...; https://urn.kb.se/re...; https://doi.org/10.4...; show less...

Abstract Subject headings

The stability of mammalian telomeres depends upon TRF2, which prevents inappropriate repair and checkpoint activation. By using a plasmid integration assay in yeasts carrying humanized telomeres, we demonstrated that TRF2 possesses the intrinsic property to both stimulate initial homologous recombination events and to prevent their resolution via its basic N-terminal domain. In human cells, we further showed that this TRF2 domain prevents telomere shortening mediated by the resolvase-associated protein SLX4 as well as GEN1 and MUS81, 2 different types of endonucleases with resolvase activities. We propose that various types of resolvase activities are kept in check by the basic N-terminal domain of TRF2 in order to favor an accurate repair of the stalled forks that occur during telomere replication. © 2014 Landes Bioscience.

By the author/editor: Saint-Leger, A.; Koelblen, M.; Civitelli, Livia; Bah, A.; Djerbi, N.; Giraud-Panis, M. ...; show more...; Londono-Vallejo, ...; Ascenzioni, F.; Gilson, E.; show less...

About the subject

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.