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Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents
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- Witt, Suzanne Tyson (author)
- Linköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Medicinska fakulteten
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- Stevens, Michael C. (author)
- Hartford Hospital, CT 06106 USA; Yale University, CT 06511 USA
- (creator_code:org_t)
- Elsevier, 2015
- 2015
- English.
- In: Psychiatry Research. - : Elsevier. - 0925-4927 .- 1872-7506. ; 232:2, s. 168-174
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- ADHD; Adolescents; Dimensionality; DTI; Superior longitudinal fasciculus
Publication and Content Type
- ref (subject category)
- art (subject category)
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