Surface functionalisation of carbon for low cost fabrication of highly stable electrochemical DNA sensors

• An alternative strategy for surface tethering of DNA probes, where highly reactive glassy carbon (GC) substrates are prepared via electrochemical hydrogenation and electrochemical/chemical chlorination is reported. Thiolated DNA probes and alkanethiols were stably immobilised on the halogenated carbon, with electrochemical chlorination being milder, thus producing less damage to the surface. Electrochemical DNA sensors prepared using this surface  chemistry on carbon with electrochemical chlorination providing an improved performance,producing a highly ordered surface and the use of lateral spacers to improve steric  accessibility to immobilised probes was not required.

Subject headings

NATURVETENSKAP  -- Kemi -- Analytisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Analytical Chemistry (hsv//eng)

Publication and Content Type

ref (subject category)

art (subject category)