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Increased frequency...
Increased frequency of late-senescent T cells lacking CD127 in chronic hepatitis C disease
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- Barathan, Muttiah (author)
- University of Malaya, Malaysia
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- Mohamed, Rosmawati (author)
- University of Malaya, Malaysia
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- Saeidi, Alireza (author)
- University of Malaya, Malaysia
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- Vadivelu, Jamuna (author)
- University of Malaya, Malaysia
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- Chang, Li Y. (author)
- University of Malaya, Malaysia
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- Gopal, Kaliappan (author)
- University of Malaya, Malaysia
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- Ram, Mani R. (author)
- University of Malaya, Malaysia
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- Ansari, Abdul W. (author)
- University of Malaya, Malaysia
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- Kamarulzaman, Adeeba (author)
- University of Malaya, Malaysia
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- Velu, Vijayakumar (author)
- Emory Vaccine Centre, GA USA
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- Larsson, Marie (author)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Shankar, Esaki M. (author)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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(creator_code:org_t)
- 2015-03-16
- 2015
- English.
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In: European Journal of Clinical Investigation. - : Wiley. - 0014-2972 .- 1365-2362. ; 45:5, s. 466-474
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BackgroundHepatitis C virus (HCV) causes persistent disease in similar to 85% of infected individuals, where the viral replication appears to be tightly controlled by HCV-specific CD8+ T cells. Accumulation of senescent T cells during infection results in considerable loss of functional HCV-specific immune responses. Materials and methodsWe characterized the distinct T-cell phenotypes based on the expression of costimulatory molecules CD28 and CD27, senescence markers PD-1 and CD57, chronic immune activation markers CD38 and HLA-DR, and survival marker CD127 (IL-7R) by flow cytometry following activation of T cells using HCV peptides and phytohemagglutinin. ResultsHCV-specific CD4+ and CD8+ T cells from chronic HCV (CHC) patients showed increased expression of PD-1. Furthermore, virus-specific CD4+ T cells of CHC-infected subjects displayed relatively increased expression of HLA-DR and CD38 relative to HCV-specific CD8+ T cells. The CD4+ and CD8+ T cells from HCV-infected individuals showed significant increase of late-differentiated T cells suggestive of immunosenescence. In addition, we found that the plasma viral loads positively correlated with the levels of CD57 and PD-1 expressed on T cells. ConclusionsChronic HCV infection results in increased turnover of late-senescent T cells that lack survival potentials, possibly contributing to viral persistence. Our findings challenge the prominence of senescent T-cell phenotypes in clinical hepatitis C infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- CD38; CD57; HCV infection; IL-7R; immunosenescence; PD-1
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Barathan, Muttia ...
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Mohamed, Rosmawa ...
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Saeidi, Alireza
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Vadivelu, Jamuna
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Chang, Li Y.
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Gopal, Kaliappan
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show more...
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Ram, Mani R.
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Ansari, Abdul W.
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Kamarulzaman, Ad ...
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Velu, Vijayakuma ...
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Larsson, Marie
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Shankar, Esaki M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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European Journal ...
- By the university
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Linköping University