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Enhanced meta-analy...
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
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- Tsoi, Lam C. (author)
- University of Michigan, MI 48109 USA
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- Spain, Sarah L. (author)
- Kings Coll London, England; Wellcome Trust Sanger Institute, England
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- Ellinghaus, Eva (author)
- University of Kiel, Germany
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- Stuart, Philip E. (author)
- University of Michigan, MI 48109 USA
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- Capon, Francesca (author)
- Kings Coll London, England
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- Knight, Jo (author)
- Centre Addict and Mental Heatlh, Canada; Guys and St Thomas NHS Fdn Trust, England
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- Tejasvi, Trilokraj (author)
- University of Michigan, MI 48109 USA
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- Kang, Hyun M. (author)
- University of Michigan, MI 48109 USA
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- Allen, Michael H. (author)
- Kings Coll London, England
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- Lambert, Sylviane (author)
- University of Michigan, MI 48109 USA
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- Stoll, Stefan W. (author)
- University of Michigan, MI 48109 USA
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- Weidinger, Stephan (author)
- University of Kiel, Germany
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- Gudjonsson, Johann E. (author)
- University of Michigan, MI 48109 USA
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- Koks, Sulev (author)
- University of Tartu, Estonia; University of Tartu, Estonia
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- Kingo, Kulli (author)
- University of Tartu, Estonia
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- Esko, Tonu (author)
- University of Tartu, Estonia
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- Das, Sayantan (author)
- University of Michigan, MI 48109 USA
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- Metspalu, Andres (author)
- University of Tartu, Estonia
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- Weichenthal, Michael (author)
- University of Kiel, Germany
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- Enerbäck, Charlotta (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Krueger, Gerald G. (author)
- University of Utah, UT 84132 USA
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- Voorhees, John J. (author)
- University of Michigan, MI 48109 USA
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- Chandran, Vinod (author)
- University of Toronto, Canada
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- Rosen, Cheryl F. (author)
- University of Toronto, Canada
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- Rahman, Proton (author)
- Mem University, Canada
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- Gladman, Dafna D. (author)
- University of Toronto, Canada
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- Reis, Andre (author)
- University of Erlangen Nurnberg, Germany
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- Nair, Rajan P. (author)
- University of Michigan, MI 48109 USA
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- Franke, Andre (author)
- University of Kiel, Germany
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- Barker, Jonathan N. W. N. (author)
- Kings Coll London, England
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- Abecasis, Goncalo R. (author)
- University of Michigan, MI 48109 USA
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- Trembath, Richard C. (author)
- Queen Mary University of London, England
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- Elder, James T. (author)
- University of Michigan, MI 48109 USA; Ann Arbor Vet Affairs Hospital, MI 48105 USA
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(creator_code:org_t)
- 2015-05-05
- 2015
- English.
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In: Nature Communications. - : Nature Publishing Group: Nature Communications. - 2041-1723. ; 6:7001
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci at genome-wide significance (Pless than5 x 10(-8)). The newly identified signals include two that reside in intergenic regions (1q31.1 and 5p13.1) and three residing near PLCL2 (3p24.3), NFKBIZ (3q12.3) and CAMK2G (10q22.2). We further demonstrate that NFKBIZ is a TRAF3IP2-dependent target of IL-17 signalling in human skin keratinocytes, thereby functionally linking two strong candidate genes. These results further integrate the genetics and immunology of psoriasis, suggesting new avenues for functional analysis and improved therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tsoi, Lam C.
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Spain, Sarah L.
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Ellinghaus, Eva
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Stuart, Philip E ...
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Capon, Francesca
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Knight, Jo
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show more...
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Tejasvi, Trilokr ...
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Kang, Hyun M.
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Allen, Michael H ...
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Lambert, Sylvian ...
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Stoll, Stefan W.
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Weidinger, Steph ...
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Gudjonsson, Joha ...
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Koks, Sulev
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Kingo, Kulli
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Esko, Tonu
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Das, Sayantan
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Metspalu, Andres
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Weichenthal, Mic ...
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Enerbäck, Charlo ...
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Krueger, Gerald ...
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Voorhees, John J ...
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Chandran, Vinod
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Rosen, Cheryl F.
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Rahman, Proton
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Gladman, Dafna D ...
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Reis, Andre
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Nair, Rajan P.
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Franke, Andre
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Barker, Jonathan ...
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Abecasis, Goncal ...
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Trembath, Richar ...
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Elder, James T.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
- Articles in the publication
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Nature Communica ...
- By the university
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Linköping University