Search: onr:"swepub:oai:DiVA.org:liu-119904" >
Outcome and Treatme...
Outcome and Treatment of Elderly Patients with ANCA-Associated Vasculitis
-
- Weiner, Maria (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
-
- Goh, Su Mein (author)
- University College London Centre for Nephrology, Royal Free Hospital, London, United Kingdom
-
- Mohammad, Aladdin (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden; Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, United Kingdom
-
show more...
-
- Hruskova, Zdenka (author)
- Charles Univ Prague, Fac Med 1, Dept Nephrol, Prague, Czech Republic, Gen Univ Hosp, Prague, Czech Republic
-
- Tanna, Anisha (author)
- Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic
-
- Bruchfeld, Annette (author)
- Karolinska Institutet,Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England, Karolinska Univ Hosp, Dept Renal Med, Stockholm, Sweden
-
- Selga, Daina (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Renal Medicine, Karolinska University Hospital, and Department of Clinical Sciences, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; and.
-
- Chocova, Zdenka (author)
- Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republi
-
- Westman, Kerstin (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö, Sweden
-
- Eriksson, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Reumatologiska kliniken i Östergötland,Medicinska fakulteten
-
- Pusey, Charles D (author)
- Department of Medicine, Imperial College London, London, United Kingdom;
-
- Tesar, Vladimir (author)
- Department of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic;
-
- Salama, Alan D (author)
- University College London Centre for Nephrology, Royal Free Hospital, London, United Kingdom;
-
- Segelmark, Mårten (author)
- Lund University,Lunds universitet,Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
-
show less...
-
(creator_code:org_t)
- American Society of Nephrology, 2015
- 2015
- English.
-
In: Clinical journal of the American Society of Nephrology : CJASN. - : American Society of Nephrology. - 1555-905X. ; 10:7, s. 1128-1135
- Related links:
-
https://liu.diva-por... (primary) (Raw object)
-
show more...
-
https://portal.resea... (primary) (free)
-
http://www.ncbi.nlm....
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.2...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND AND OBJECTIVES: ANCA-associated vasculitis is commonly found in elderly patients, but there are few data concerning outcome and treatment in the highest age groups.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Consecutive patients (N=151) presenting between 1997 and 2009 were retrospectively included from local registries in six centers in Sweden, the United Kingdom, and the Czech Republic if diagnosed with microscopic polyangiitis or granulomatosis with polyangiitis at age ≥75 years during the study period. Patients were followed until 2 years from diagnosis or death. Data on survival and renal function were analyzed with respect to age, sex, ANCA specificity, renal function, C-reactive protein, comorbidities, and Birmingham Vasculitis Activity Score at diagnosis as well as treatment during the first month.RESULTS: Median follow-up was 730 days (interquartile range, 244-730). Overall 1-year survival was 71.5% and 2-year survival was 64.6%. Older age, higher creatinine, and lower Birmingham Vasculitis Activity Score were associated with higher mortality in multivariable analysis. Patients who were not treated with standard immunosuppressive therapy had significantly worse survival. Renal survival was 74.8% at 1 year. No new cases of ESRD occurred during the second year. High creatinine at diagnosis was the only significant predictor of renal survival in multivariable analysis.CONCLUSIONS: ANCA-associated vasculitis is a disease with substantial mortality and morbidity among elderly patients. This study showed a better prognosis for those who received immunosuppressive treatment and those who were diagnosed before having developed advanced renal insufficiency.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- ANCA
- glomerulonephritis
- survival
- vasculitis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Weiner, Maria
-
Goh, Su Mein
-
Mohammad, Aladdi ...
-
Hruskova, Zdenka
-
Tanna, Anisha
-
Bruchfeld, Annet ...
-
show more...
-
Selga, Daina
-
Chocova, Zdenka
-
Westman, Kerstin
-
Eriksson, Per
-
Pusey, Charles D
-
Tesar, Vladimir
-
Salama, Alan D
-
Segelmark, Mårte ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
Clinical journal ...
- By the university
-
Linköping University
-
Lund University
-
Karolinska Institutet