Pain and activity limitations in women and men with contemporary treated early RA compared to 10 years ago: the Swedish TIRA project

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Ahlstrand, IngerJönköping University,HHJ, Avdelningen för rehabilitering,HHJ. ADULT (author)

Pain and activity limitations in women and men with contemporary treated early RA compared to 10 years ago: the Swedish TIRA project

Article/chapterEnglish2015

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2015-03-19
Informa Healthcare,2015
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-121326
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-121326URI
https://doi.org/10.3109/03009742.2014.997285DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-26391URI

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Language:English
Summary in:English

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Funding Agencies|Medical Research Council of Southeast Sweden (FORSS); Academy for Health and Care Jonkoping County Council (Futurum)
Objectives: To study differences regarding pain and activity limitations during the 3 years following diagnosis in women and men with contemporary treated early RA compared with their counterparts who were diagnosed 10 years earlier. Method: This study was based on patients recruited to the Early Intervention in RA (TIRA) project. In the first cohort (TIRA-1) 320 patients were included in time for diagnosis during 1996-1998 and 463 patients were included in the second cohort (TIRA-2) during 2006-2009. Disease activity, pain intensity (Visual Analogue Scale, VAS), bodily pain (BP) in the 36-item Short Form Health Survey (SF-36), activity limitations (Health Assessment Questionnaire, HAQ), and medication were reported at inclusion and at follow-up after 1, 2, and 3 years. Results: Disease activity, pain, and activity limitations were pronounced at inclusion across both genders and in both cohorts, with some improvement observed during the first year after diagnosis. Disease activity did not differ between cohorts at inclusion but was significantly lower at the follow-ups in the TIRA-2 cohort, in which the patients were prescribed traditional disease-modifying anti-rheumatic drugs (DMARDs) and biological agents more frequently. In TIRA-2, patients reported significantly lower pain and activity limitations at all follow-ups, with men reporting lower pain than women. Women reported significantly higher activity limitations at all time points in TIRA-2. Conclusions: Pain and activity limitations were still pronounced in the contemporary treated early RA cohort compared with their counterparts diagnosed 10 years earlier and both of these factors need to be addressed in clinical settings.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences hsv//eng

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Thyberg, IngridLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linköping University(Swepub:liu)ingth40 (author)
Falkmer, TorbjörnJönköping University,Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum,School of Health Sciences, Jönköping University, Jönköping, Sweden; School of Occupational Therapy and Social Work, CHIRI, Curtin University, Perth, WA, Australia,HHJ, Avdelningen för rehabilitering(Swepub:hj)FaTo (author)
Dahlström, ÖrjanLinköpings universitet,Handikappvetenskap,Filosofiska fakulteten,Institutet för handikappvetenskap (IHV),Linköping University(Swepub:liu)orjda41 (author)
Björk, MathildaJönköping University,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Rehabenheten HMC,School of Health Sciences, Jönköping University, Jönköping, Sweden,HHJ, Avdelningen för rehabilitering,HHJ. ADULT(Swepub:hj)bjom (author)
Jönköping UniversityHHJ, Avdelningen för rehabilitering (creator_code:org_t)

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In:Scandinavian Journal of Rheumatology: Informa Healthcare44:4, s. 259-2640300-97421502-7732

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