Plasma Matrix Metalloproteinase-9 Levels Predict First-Time Coronary Heart Disease: An 8-Year Follow-Up of a Community-Based Middle Aged Population

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Garvin, PeterLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland (author)

Plasma Matrix Metalloproteinase-9 Levels Predict First-Time Coronary Heart Disease: An 8-Year Follow-Up of a Community-Based Middle Aged Population

Article/chapterEnglish2015

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2015-09-21
PUBLIC LIBRARY SCIENCE,2015
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LIBRIS-ID:oai:DiVA.org:liu-122112
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122112URI
https://doi.org/10.1371/journal.pone.0138290DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies|Swedish Research Council [2004-1881]; Swedish Heart and Lung Foundation [2004053]
Background The enzyme in matrix metalloproteinase (MMP)-9 has been suggested to be an important determinant of plaque degradation. While several studies have shown elevated levels in patients with coronary heart disease, results in prospective population based studies evaluating MMP-9 in relation to first time coronary events have been inconclusive. As of today, there are four published studies which have measured MMP-9 in serum and none using plasma. Measures of MMP-9 in serum have been suggested to have more flaws than measures in plasma. Aim To investigate the independent association between plasma levels of MMP-9 and first-time incidence of coronary events in an 8-year follow-up. Material and Methods 428 men and 438 women, aged 45-69 years, free of previous coronary events and stroke at baseline, were followed-up. Adjustments were made for sex, age, socioeconomic position, behavioral and cardiovascular risk factors, chronic disease at baseline, depressive symptoms, interleukin-6 and C-reactive protein. Results 53 events were identified during a risk-time of 6 607 person years. Hazard ratio (HR) for MMP-9 after adjustment for all covariates were HR = 1.44 (1.03 to 2.02, p = 0.033). Overall, the effect of adjustments for other cardiovascular risk factors was low. Conclusion Levels of plasma MMP-9 are independently associated with risk of first-time CHD events, regardless of adjustments. These results are in contrast to previous prospective population-based studies based on MMP-9 in serum. It is essential that more studies look at MMP-9 levels in plasma to further evaluate the association with first coronary events.

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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng

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Jonasson, LenaLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)lenjo59 (author)
Nilsson, LennartLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)lenni29 (author)
Falk, MagnusLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland(Swepub:liu)magfa32 (author)
Kristenson, MargaretaLinköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten(Swepub:liu)markr44 (author)
Linköpings universitetAvdelningen för samhällsmedicin (creator_code:org_t)

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In:PLOS ONE: PUBLIC LIBRARY SCIENCE10:9, s. e0138290-1932-6203

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By the author/editor: Garvin, Peter; Jonasson, Lena; Nilsson, Lennart; Falk, Magnus; Kristenson, Marg ...

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