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A variety of thiophene based ligands for detection of protein aggregates by surface plasmon resonance
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- Johansson, Leif B. G. (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Bäck, Marcus (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Lantz, Linda (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- English.
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Abstract
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- By attaching an azide functional group via a tetraethylene glycol linker to the α-terminal position of a variety of oligothiophenes, thiophene-based ligands that can be utilized for detection of protein aggregates with surface plasmon resonance have been developed. All ligands displayed selectivity towards recombinant amyloid fibrils and the LCO/protein aggregate interaction could be detected by fluorescence as well as by surface plasmon resonance.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
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- Nygren, Patrik
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- NATURAL SCIENCES
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- Linköping University
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