Protective properties of lysozyme on β-amyloid pathology: implications for Alzheimer disease

Helmfors, LindaLinköpings universitet,Molekylär Bioteknik,Tekniska fakulteten (author)

Protective properties of lysozyme on β-amyloid pathology : implications for Alzheimer disease

The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-β1-40 in vitro. In this study we found that patients with Alzheimer disease have increased lysozyme levels in the cerebrospinal fluid and lysozyme co-localized with amyloid-β in plaques. In Drosophila neuronal co-expression of lysozyme and amyloid-β1-42 reduced the formation of soluble and insoluble amyloid-β species, prolonged survival and improved the activity of amyloid-β1-42 transgenic flies. This suggests that lysozyme levels rise in Alzheimer disease as a compensatory response to amyloid-β increases and aggregation. In support of this, in vitro aggregation assays revealed that lysozyme associates with amyloid-β1-42 and alters its aggregation pathway to counteract the formation of toxic amyloid-β species. Overall, these studies establish a protective role for lysozyme against amyloid-β associated toxicities and identify increased lysozyme in patients with Alzheimer disease. Therefore, lysozyme has potential as a new biomarker as well as a therapeutic target for Alzheimer disease.

Boman, AndreaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)andar41 (author)
Civitelli, LiviaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)livci24 (author)
Nath, SangeetaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)sanna47 (author)
Sandin, LinneaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)linsa35 (author)
Janefjord, CamillaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)camja19 (author)
McCann, HeatherNeuroscience Research Australia and University of New South Wales, Australia (author)
Zetterberg, HenrikClinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden / UCL Institute of Neurology, Queen Square, London, United Kingdom (author)
Blennow, KajClinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden (author)
Halliday, GlendaUCL Institute of Neurology, Queen Square, London, United Kingdom (author)
Brorsson, Ann-ChristinLinköpings universitet,Molekylär Bioteknik,Tekniska fakulteten(Swepub:liu)annbr05 (author)
Kågedal, KatarinaLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)katka10 (author)
Linköpings universitetMolekylär Bioteknik (creator_code:org_t)

By the author/editor: Helmfors, Linda; Boman, Andrea; Civitelli, Livia; Nath, Sangeeta; Sandin, Linnea; Janefjord, Camil ...; show more...; McCann, Heather; Zetterberg, Henr ...; Blennow, Kaj; Halliday, Glenda; Brorsson, Ann-Ch ...; Kågedal, Katarin ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

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