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Search: onr:"swepub:oai:DiVA.org:liu-122643" > Phylogenetic analys...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005468naa a2200565 4500
001oai:DiVA.org:liu-122643
003SwePub
008151113s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132246530
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1226432 URI
0247 a https://doi.org/10.1002/ijc.296912 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1322465302 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wangsa, Darawaleeu NCI, MD 20892 USA; Karolinska University Hospital, Sweden4 aut
2451 0a Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis
264 c 2015-08-28
264 1b John Wiley & Sons,c 2016
338 a print2 rdacarrier
500 a Funding Agencies|National Institutes of Health (NIH), National Cancer Institute, National Library of Medicine (Intramural Research Program) NIH Extramural grants [1R01CA140214, 1R01AI076318]; Swedish Cancer Society (Cancerfonden); Cancer Society of Stockholm (Cancerforeningen); Laryngfonden; Karolinska Institutet
520 a Oral tongue squamous cell carcinoma (OTSCC) is associated with poor prognosis. To improve prognostication, we analyzed four gene probes (TERC, CCND1, EGFR and TP53) and the centromere probe CEP4 as a marker of chromosomal instability, using fluorescence in situ hybridization (FISH) in single cells from the tumors of sixty-five OTSCC patients (Stage I, n=15; Stage II, n=30; Stage III, n=7; Stage IV, n=13). Unsupervised hierarchical clustering of the FISH data distinguished three clusters related to smoking status. Copy number increases of all five markers were found to be correlated to non-smoking habits, while smokers in this cohort had low-level copy number gains. Using the phylogenetic modeling software FISHtrees, we constructed models of tumor progression for each patient based on the four gene probes. Then, we derived test statistics on the models that are significant predictors of disease-free and overall survival, independent of tumor stage and smoking status in multivariate analysis. The patients whose tumors were modeled as progressing by a more diverse distribution of copy number changes across the four genes have poorer prognosis. This is consistent with the view that multiple genetic pathways need to become deregulated in order for cancer to progress. Whats new? Oral tongue squamous cell carcinoma (OTSCC) is a rare head and neck cancer that typically is asymptomatic in early stages. Hence, in order to improve prognosis in OTSCC, predictive biomarkers that are independent of tumor stage must be identified. Here, using four fluorescence in situ hybridization (FISH) gene probes and the software FISHtrees, phylogenetic tree models of tumor progression in OTSCC patients were constructed. Analyses of the models showed that the more diverse the changes within the four marker genes, the worse the outcome in OTSCC. The markers predicted survival independent of smoking behavior and tumor stage.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a oral tongue cancer
653 a FISH
653 a genetic markers
653 a phylogenetic modeling
653 a HPV
7001 a Akhter Chowdhury, Salimu Carnegie Mellon University, PA 15213 USA; Carnegie Mellon University, PA 15213 USA4 aut
7001 a Ryott, Michaelu Sophiahemmet Hospital, Sweden4 aut
7001 a Michael Gertz, E.u NIH, MD 20892 USA4 aut
7001 a Elmberger, Goranu Örebro University Hospital, Sweden4 aut
7001 a Auer, Gertu Karolinska Institutet,Karolinska University Hospital, Sweden4 aut
7001 a Åvall Lundqvist, Elisabethu Karolinska Institutet,Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Karolinska University Hospital, Sweden4 aut0 (Swepub:liu)eliav51
7001 a Kueffer, Stefanu University of Medical Centre Gottingen, Germany4 aut
7001 a Stroebel, Philippu University of Medical Centre Gottingen, Germany4 aut
7001 a Schaeffer, Alejandro A.u NIH, MD 20892 USA4 aut
7001 a Schwartz, Russellu Carnegie Mellon University, PA 15213 USA; Carnegie Mellon University, PA 15213 USA4 aut
7001 a Munck-Wikland, Evau Karolinska Institutet,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden4 aut
7001 a Ried, Thomasu NCI, MD 20892 USA4 aut
7001 a Heselmeyer-Haddad, Kerstinu NCI, MD 20892 USA4 aut
7102 a NCI, MD 20892 USA; Karolinska University Hospital, Swedenb Carnegie Mellon University, PA 15213 USA; Carnegie Mellon University, PA 15213 USA4 org
7730 t International Journal of Cancerd : John Wiley & Sonsg 138:1, s. 98-109q 138:1<98-109x 0020-7136x 1097-0215
8564 u https://europepmc.org/articles/pmc4823771?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122643
8564 8u https://doi.org/10.1002/ijc.29691
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132246530

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