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Bioengineered Corne...
Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients
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- Buznyk, Oleksiy (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,National Academic Medical Science Ukraine, Ukraine
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- Pasyechnikova, Nataliya (author)
- National Academic Medical Science Ukraine, Ukraine
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- Islam, Mohammad Mirazul (author)
- Karolinska Institutet,Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Institute, Sweden,Integrat Regenerat Med Ctr
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- Iakymenko, Stanislav (author)
- National Academic Medical Science Ukraine, Ukraine
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- Fagerholm, Per (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Ögonkliniken US
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- Griffith, May (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Institute, Sweden
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(creator_code:org_t)
- 2015-05-21
- 2015
- English.
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In: Clinical and Translational Science. - : WILEY-BLACKWELL. - 1752-8054 .- 1752-8062. ; 8:5, s. 558-562
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Abstract
Subject headings
Close
- Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Keyword
- collagen; epithelium; grafting; patients; remodeling; transplantation
Publication and Content Type
- ref (subject category)
- art (subject category)
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