Software-based on-site estimation of fractional flow reserve using standard coronary CT angiography data.

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De Geer, JakobLinköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV (author)

Software-based on-site estimation of fractional flow reserve using standard coronary CT angiography data.

Article/chapterEnglish2016

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2016-07-21
Sage Publications,2016
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:liu-123579
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-123579URI
https://doi.org/10.1177/0284185115622075DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding agencies: Department of Radiology, Region Ostergotland; Swedish Heart-Lung-foundation [20120449]
BACKGROUND: The significance of a coronary stenosis can be determined by measuring the fractional flow reserve (FFR) during invasive coronary angiography. Recently, methods have been developed which claim to be able to estimate FFR using image data from standard coronary computed tomography angiography (CCTA) exams.PURPOSE: To evaluate the accuracy of non-invasively computed fractional flow reserve (cFFR) from CCTA.MATERIAL AND METHODS: A total of 23 vessels in 21 patients who had undergone both CCTA and invasive angiography with FFR measurement were evaluated using a cFFR software prototype. The cFFR results were compared to the invasively obtained FFR values. Correlation was calculated using Spearman's rank correlation, and agreement using intraclass correlation coefficient (ICC). Sensitivity, specificity, accuracy, negative predictive value, and positive predictive value for significant stenosis (defined as both FFR ≤0.80 and FFR ≤0.75) were calculated.RESULTS: The mean cFFR value for the whole group was 0.81 and the corresponding mean invFFR value was 0.84. The cFFR sensitivity for significant stenosis (FFR ≤0.80/0.75) on a per-lesion basis was 0.83/0.80, specificity was 0.76/0.89, and accuracy 0.78/0.87. The positive predictive value was 0.56/0.67 and the negative predictive value was 0.93/0.94. The Spearman rank correlation coefficient was ρ = 0.77 (P < 0.001) and ICC = 0.73 (P < 0.001).CONCLUSION: This particular CCTA-based cFFR software prototype allows for a rapid, non-invasive on-site evaluation of cFFR. The results are encouraging and cFFR may in the future be of help in the triage to invasive coronary angiography.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
Cardiac; computed tomography angiography (CTA); heart; arteries; adults; computer applications – detection/diagnosis

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Sandstedt, MårtenLinköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)marsa80 (author)
Björkholm, AndersRegion Östergötland, Röntgenkliniken i Linköping (author)
Alfredsson, JoakimLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)joaal38 (author)
Janzon, MagnusLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)magja75 (author)
Engvall, JanLinköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)janen74 (author)
Persson, AndersLinköpings universitet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Region Östergötland, Röntgenkliniken i Linköping(Swepub:liu)andpe75 (author)
Linköpings universitetAvdelningen för radiologiska vetenskaper (creator_code:org_t)

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In:Acta Radiologica: Sage Publications57:10, s. 1186-11920284-18511600-0455

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