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No evidence for act...
No evidence for activation of TH1 or TH17 pathways in unstimulated peripheral blood mononuclear cells from children with ß-cell autoimmunity or T1D
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- Walldén (Fredriksson), Jenny, 1977- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Honkanen, Jarno (author)
- National Public Health Institute, Helsinki, Finland
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- Ilonen, Jorma (author)
- University of Kuopio and Laboratory, University of Turku, Finland
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- Ludvigsson, Johnny (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Vaarala, Outi (author)
- National Public Health Institute, Helsinki, Finland
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(creator_code:org_t)
- Dove Medical Press, 2008
- 2008
- English.
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In: Journal of Inflammation Research. - : Dove Medical Press. - 1178-7031. ; 1, s. 11-17
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http://urn.kb.se/res...
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https://liu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- INTRODUCTION:The balance between T(H)1, T(H)2, T(H)17, and regulatory T cells has been suggested to be disturbed in type 1 diabetes (T1D). We investigated this balance in peripheral blood mononuclear cells (PBMC) from children at risk of developing T1D and children with T1D.METHODS:We studied PBMC expression levels of markers related to T(H)1 (T-bet, IL-12Rβ(1), IL-12Rβ(2)), T(H)2 (GATA-3, IL-4Rα), T(H)17 (IL-17A), and regulatory T cells (Foxp3, ICOS, and CTLA-4) with real-time polymerase chain reaction from 17 children with T1D, 13 children with β-cell autoimmunity, 15 children with T1D risk-associated human leukocyte antigen (HLA) haplotypes, and 24 healthy, control children.RESULTS:We observed decreased expression levels of GATA-3 by PBMC of healthy children with autoantibodies compared to healthy, control children (p = 0.014) or children with HLA risk alleles (p = 0.032). Children with T1D demonstrated lower expression levels of T-bet, IL-12Rβ(1), and IL-4Rα both at diagnosis and 12 months later.CONCLUSION:We found no indication of aberrant activation of T(H)1, T(H)17, or Treg in peripheral blood from children with or without risk of T1D. The observed immunological differences between children at risk of and with T1D should be considered when immunopathogenesis of β-cell destruction is studied.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Transcription factor
- type 1 diabetes
- mononuclear cells
- Immunology
- Immunologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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