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Tumour exosome inte...
Tumour exosome integrins determine organotropic metastasis
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- Hoshino, Ayuko (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Costa-Silva, Bruno (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Shen, Tang-Long (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; National Taiwan University, Taiwan; National Taiwan University, Taiwan
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- Rodrigues, Goncalo (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; University of Porto, Portugal
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- Hashimoto, Ayako (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; University of Tokyo, Japan
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- Tesic Mark, Milica (author)
- Rockefeller University, NY 10065 USA
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- Molina, Henrik (author)
- Rockefeller University, NY 10065 USA
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- Kohsaka, Shinji (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Di Giannatale, Angela (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Ceder, Sophia (author)
- Karolinska Institutet
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- Singh, Swarnima (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Williams, Caitlin (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Soplop, Nadine (author)
- Rockefeller University, NY 10065 USA
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- Uryu, Kunihiro (author)
- Rockefeller University, NY 10065 USA
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- Pharmer, Lindsay (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- King, Tari (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Bojmar, Linda (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Davies, Alexander E. (author)
- University of Calif Berkeley, CA 94720 USA
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- Ararso, Yonathan (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Zhang, Tuo (author)
- Weill Cornell Med, NY 10021 USA
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- Zhang, Haiying (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Hernandez, Jonathan (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Weiss, Joshua M. (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Dumont-Cole, Vanessa D. (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Kramer, Kimberly (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Wexler, Leonard H. (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Narendran, Aru (author)
- Alberta Childrens Prov Gen Hospital, Canada
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- Schwartz, Gary K. (author)
- Columbia University, NY 10032 USA
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- Healey, John H. (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Sandström, Per (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Jorgen Labori, Knut (author)
- Oslo University Hospital, Norway
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- Kure, Elin H. (author)
- Oslo University Hospital, Norway
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- Grandgenett, Paul M. (author)
- University of Nebraska Medical Centre, NE 68198 USA
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- Hollingsworth, Michael A. (author)
- University of Nebraska Medical Centre, NE 68198 USA
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- de Sousa, Maria (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; University of Porto, Portugal
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- Kaur, Sukhwinder (author)
- University of Nebraska Medical Centre, NE 68198 USA
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- Jain, Maneesh (author)
- University of Nebraska Medical Centre, NE 68198 USA
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- Mallya, Kavita (author)
- University of Nebraska Medical Centre, NE 68198 USA
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- Batra, Surinder K. (author)
- University of Nebraska Medical Centre, NE 68198 USA
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- Jarnagin, William R. (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Brady, Mary S. (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Fodstad, Oystein (author)
- Oslo University Hospital, Norway; University of Oslo, Norway
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- Muller, Volkmar (author)
- University of Medical Centre, Germany
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- Pantel, Klaus (author)
- University of Medical Centre Hamburg Eppendorf, Germany
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- Minn, Andy J. (author)
- University of Penn, PA 19104 USA
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- Bissell, Mina J. (author)
- University of Calif Berkeley, CA 94720 USA
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- Garcia, Benjamin A. (author)
- University of Penn, PA 19104 USA
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- Kang, Yibin (author)
- Princeton University, NJ 08544 USA; Rutgers Cancer Institute New Jersey, NJ 08903 USA
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- Rajasekhar, Vinagolu K. (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA
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- Ghajar, Cyrus M. (author)
- Fred Hutchinson Cancer Research Centre, WA 98109 USA
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- Matei, Irina (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA
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- Peinado, Hector (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; Spanish National Cancer Research Centre CNIO, Spain
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- Bromberg, Jacqueline (author)
- Mem Sloan Kettering Cancer Centre, NY 10065 USA; Weill Cornell Med, NY 10021 USA
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- Lyden, David (author)
- Weill Cornell Med, NY 10021 USA; Weill Cornell Med, NY 10021 USA; Mem Sloan Kettering Cancer Centre, NY 10065 USA
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(creator_code:org_t)
- 2015-10-28
- 2015
- English.
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In: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 527:7578, s. 329-
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Ever since Stephen Pagets 1889 hypothesis, metastatic organotropism has remained one of cancers greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver-and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells. We show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche. Treatment with exosomes from lung-tropic models redirected the metastasis of bone-tropic tumour cells. Exosome proteomics revealed distinct integrin expression patterns, in which the exosomal integrins alpha(6)beta(4) and alpha(6)beta(1) were associated with lung metastasis, while exosomal integrin alpha(v)beta(5) was linked to liver metastasis. Targeting the integrins alpha(6)beta(4) and alpha(v)beta(5) decreased exosome uptake, as well as lung and liver metastasis, respectively. We demonstrate that exosome integrin uptake by resident cells activates Src phosphorylation and pro-inflammatory S100 gene expression. Finally, our clinical data indicate that exosomal integrins could be used to predict organ-specific metastasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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To the university's database
- By the author/editor
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Hoshino, Ayuko
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Costa-Silva, Bru ...
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Shen, Tang-Long
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Rodrigues, Gonca ...
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Hashimoto, Ayako
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Tesic Mark, Mili ...
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show more...
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Molina, Henrik
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Kohsaka, Shinji
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Di Giannatale, A ...
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Ceder, Sophia
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Singh, Swarnima
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Williams, Caitli ...
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Soplop, Nadine
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Uryu, Kunihiro
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Pharmer, Lindsay
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King, Tari
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Bojmar, Linda
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Davies, Alexande ...
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Ararso, Yonathan
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Zhang, Tuo
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Zhang, Haiying
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Hernandez, Jonat ...
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Weiss, Joshua M.
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Dumont-Cole, Van ...
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Kramer, Kimberly
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Wexler, Leonard ...
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Narendran, Aru
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Schwartz, Gary K ...
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Healey, John H.
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Sandström, Per
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Jorgen Labori, K ...
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Kure, Elin H.
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Grandgenett, Pau ...
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Hollingsworth, M ...
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de Sousa, Maria
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Kaur, Sukhwinder
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Jain, Maneesh
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Mallya, Kavita
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Batra, Surinder ...
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Jarnagin, Willia ...
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Brady, Mary S.
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Fodstad, Oystein
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Muller, Volkmar
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Pantel, Klaus
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Minn, Andy J.
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Bissell, Mina J.
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Garcia, Benjamin ...
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Kang, Yibin
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Rajasekhar, Vina ...
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Ghajar, Cyrus M.
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Matei, Irina
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Peinado, Hector
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Bromberg, Jacque ...
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Lyden, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Nature
- By the university
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Linköping University
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Karolinska Institutet