Search: onr:"swepub:oai:DiVA.org:liu-127436" >
Experimental Neurom...
Experimental Neuromyelitis Optica Induces a Type I Interferon Signature in the Spinal Cord
-
- Oji, Satoru (author)
- Medical University of Vienna, Austria
-
- Nicolussi, Eva-Maria (author)
- Medical University of Vienna, Austria
-
- Kaufmann, Nathalie (author)
- Medical University of Vienna, Austria
-
show more...
-
- Zeka, Bleranda (author)
- Medical University of Vienna, Austria
-
- Schanda, Kathrin (author)
- Medical University of Innsbruck, Austria
-
- Fujihara, Kazuo (author)
- Tohoku University, Japan; Tohoku University, Japan
-
- Illes, Zsolt (author)
- University of Southern Denmark, Denmark
-
- Dahle, Charlotte (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
-
- Reindl, Markus (author)
- Medical University of Innsbruck, Austria
-
- Lassmann, Hans (author)
- Medical University of Vienna, Austria
-
- Bradl, Monika (author)
- Medical University of Vienna, Austria
-
show less...
-
(creator_code:org_t)
- 2016-03-18
- 2016
- English.
-
In: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 11:3, s. e0151244-
- Related links:
-
https://liu.diva-por... (primary) (Raw object)
-
show more...
-
https://journals.plo...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Neuromyelitis optica (NMO) is an acute inflammatory disease of the central nervous system (CNS) which predominantly affects spinal cord and optic nerves. Most patients harbor pathogenic autoantibodies, the so-called NMO-IgGs, which are directed against the water channel aquaporin 4 (AQP4) on astrocytes. When these antibodies gain access to the CNS, they mediate astrocyte destruction by complement-dependent and by antibody-dependent cellular cytotoxicity. In contrast to multiple sclerosis (MS) patients who benefit from therapies involving type I interferons (I-IFN), NMO patients typically do not profit from such treatments. How is I-IFN involved in NMO pathogenesis? To address this question, we made gene expression profiles of spinal cords from Lewis rat models of experimental neuromyelitis optica (ENMO) and experimental autoimmune encephalomyelitis (EAE). We found an upregulation of I-IFN signature genes in EAE spinal cords, and a further upregulation of these genes in ENMO. To learn whether the local I-IFN signature is harmful or beneficial, we induced ENMO by transfer of CNS antigen-specific T cells and NMO-IgG, and treated the animals with I-IFN at the very onset of clinical symptoms, when the blood-brain barrier was open. With this treatment regimen, we could amplify possible effects of the I-IFN induced genes on the transmigration of infiltrating cells through the blood brain barrier, and on lesion formation and expansion, but could avoid effects of I-IFN on the differentiation of pathogenic T and B cells in the lymph nodes. We observed that I-IFN treated ENMO rats had spinal cord lesions with fewer T cells, macrophages/activated microglia and activated neutrophils, and less astrocyte damage than their vehicle treated counterparts, suggesting beneficial effects of I-IFN.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
PLOS ONE
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Oji, Satoru
-
Nicolussi, Eva-M ...
-
Kaufmann, Nathal ...
-
Zeka, Bleranda
-
Schanda, Kathrin
-
Fujihara, Kazuo
-
show more...
-
Illes, Zsolt
-
Dahle, Charlotte
-
Reindl, Markus
-
Lassmann, Hans
-
Bradl, Monika
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
PLOS ONE
- By the university
-
Linköping University