Search: onr:"swepub:oai:DiVA.org:liu-12804" >
Tumour growth fract...
Tumour growth fraction and apoptosis in salivary gland acinic cell carcinomas : Prognostic implications of Ki-67 and bcl-2 expression and of in situ end labelling (TUNEL)
-
Hellquist, Henrik B. (author)
-
- Sundelin, Kaarina (author)
- Östergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US
-
- DiBacco, A. (author)
- Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan University School of Medicine, Milan, Italy
-
show more...
-
- Tytor, Maria (author)
- Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
-
- Manzotti, Michela (author)
- Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan University School of Medicine, Milan, Italy
-
- Viale, Giuseppe J. (author)
- Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan University School of Medicine, Milan, Italy
-
show less...
-
(creator_code:org_t)
- 1997
- 1997
- English.
-
In: The Journal of Pathology. - 0031-3025 .- 1465-3931. ; 181:3, s. 323-329
- Related links:
-
http://urn.kb.se/res...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- bcl-2 protein and Ki-67 (MIB-1) were studied in 32 acinic cell carcinomas (ACCs), all with a minimum of 5 years' clinical follow-up. Tumour apoptosis was evaluated by TdT dUTP nick end labelling (TUNEL) and by morphological criteria. Five patients died of their disease. Patients with stage I tumours had significantly better survival compared with other stages (P<0·05). Patients with MIB-1-negative tumours had significantly better survival than patients with MIB-1-positive tumours (P=0·05). This study confirms a previous report that MIB-1 is an independent prognostic factor for survival in patients with ACC. Stage I tumours had high expression of bcl-2 protein, but there was no difference when compared with other stages. TUNEL positivity was most prevalent in stage I tumours, compared with stages II, III, and IV (P<0·05), probably indicating more apoptosis. This could imply a capacity of stage I tumours ('early tumours') for early selection of tumour cells for elimination by apoptosis. There was no significant difference between expression of bcl-2 and TUNEL, between these parameters and clinical outcome, or between any parameter and morphological subclassification. We conclude that MIB-1 has prognostic value in ACC. Clinical staging, bcl-2, and TUNEL are also potentially useful as prognostic markers.
Keyword
- apoptosis
- bcl-2
- TUNEL
- end labelling
- salivary neoplasm
- Ki-67
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database