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- Bock (Seifert), OliverLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet (author)
Studies of Transforming Growth Factors Beta 1–3 and their Receptors I and II in Fibroblast of Keloids and Hypertrophic Scars
- Article/chapterEnglish2005
Publisher, publication year, extent ...
- Medical Journals Sweden AB,2005
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-12813
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12813URI
- https://doi.org/10.1080/00015550410025453DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Keloids are benign skin tumours occurring during wound healing in genetically predisposed patients. They are characterized by an abnormal deposition of extracellular matrix components, particularly collagen. There is uncertain evidence that transforming growth factor-beta (TGFβ) is involved in keloid formation. Therefore we investigated the expression of TGFβ1, 2 and 3 and their receptors in keloids, hypertrophic scars and normal skin. Dermal fibroblasts were obtained from punch biopsies of patients with keloids and hypertrophic scars and from normal skin of healthy individuals. Total RNA was isolated and the expression of TGFβ1, 2 and 3 and of TGFβ receptors I and II (TGFβRI and II) was analysed by real-time PCR using the Lightcycler technique. Our data demonstrate significantly lower TGFβ2 mRNA expression in hypertrophic scar fibroblasts as compared with fibroblasts derived from keloids and normal skin (p<0.05). In contrast, TGFβ3 mRNA expression was significantly lower in keloid fibroblasts in comparison with fibroblasts derived from hypertrophic scar and normal skin (p<0.01). TGFβRI mRNA expression was significantly decreased in hypertrophic scar fibroblasts (p<0.01) and TGFβRII mRNA expression was decreased in keloids compared with hypertrophic scar fibroblasts (p<0.001), The ratio of TGFβRI/TGFβRII expression was increased in keloids compared with hypertrophic scar and normal skin fibroblasts. As recently supposed, an increased TGFβRI/TGFβRII ratio could promote fibrosis. Therefore our data support a possible role of TGFβRI and TGFβRII in combination with a certain TGFβ expression pattern as fibrosis-inducing factors in keloids.
Subject headings and genre
- wound healing
- fibroblasts
- TGFβ receptors
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Yu, HaiyanDepartment of Dermatology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, (author)
- Zitron, SwantjeDepartment of Dermatology, University of Kiel, Kiel, Germany (author)
- Bayat, ArdeshirSchool of Biological Sciences, University of Manchester, Manchester, UK (author)
- Ferguson, Mark WJSchool of Biological Sciences, University of Manchester, Manchester, UK (author)
- Mrowietz, UlrichDepartment of Dermatology, University of Kiel, Kiel, Germany (author)
- Linköpings universitetInstitutionen för klinisk och experimentell medicin (creator_code:org_t)
Related titles
- In:Acta Dermato-Venereologica: Medical Journals Sweden AB85:3, s. 216-2200001-5555
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